Table 4: Regression slopes with p-values by age and gender for the models fitted for log10 transformed values of thyroid stimulating hormone (TSH in nIU/mL), free triiodothyronine (FT3 in fg/mL), free thyroxin (FT4 in pg/dL), total triiodothyronine (TT3 in pg/dL), total thyroxin (TT4 in ng/mL), and thyroglobulin (TGN in fg/mL) when association with blood lead was investigated. Data from National Health and Nutrition Examination Survey 2007-2012. Statistically significant associations are shown in bold letters.
| Gender: IOS | Independent variable | TSH | FT3 | FT4 | TT3 | TT4 | TGN |
|---|---|---|---|---|---|---|---|
| Male: IOD* | Use other drugs | -0.037065779 (0.28) | -0.008215337 (0.09) | 0.0103028727 (0.26) | -0.012609734 (0.17) | 0.014032962 (0.11) | 0.0065196708 (0.87) |
| Fasting in hours | -0.000612081 (0.73) | 0.0016496535 (0) | 0.0007985239 (0.02) | 0.0016788756 (0.02) | 0.0003806791 (0.45) | 0.0026515297 (0.53) | |
| Poverty income ratio | 0.0015097725 (0.8) | -0.002249327 (0.07) | -0.000979113 (0.56) | -0.002983687 (0.18) | -0.001726884 (0.25) | -0.001890045 (0.87) | |
| Log10 of Body Mass Index | 0.1353845906 (0.32) | 0.0406589662 (0.03) | -0.001868129 (0.96) | 0.099276504 (0.03) | 0.0627047093 (0.13) | 0.0712478469 (0.71) | |
| Log10 of Serum Albumin | 0.6647769285 (0.1) | 0.223483551 (0) | -0.097939711 (0.29) | 0.3531044459 (0) | -0.076536462 (0.41) | -0.673733775 (0.22) | |
| Log10 of Blood Lead | 0.1105665567 (0.04) | -0.008447674 (0.13) | -0.01377589 (0.2) | -0.012574298 (0.23) | -0.008348064 (0.34) | 0.0302216627 (0.64) | |
| NHANES survey cycle | 0.0019232639 (0.92) | -0.003236359 (0.29) | 0.0121946118 (0) | -0.000720082 (0.89) | -0.010788304 (0.01) | 0.0139275255 (0.44) | |
| R2 in percent | 2.8 | 30.9 | 6.2 | 18.3 | 5.0 | 8.0 | |
| Male: IOR* | Use other drugs | 0.023149433 (0.36) | -0.017148042 (0) | 0.0060513245 (0.35) | -0.024017872 (0) | 0.009344698 (0.32) | -0.060085942 (0.03) |
| Fasting in hours | 0.0007070414 (0.59) | 0.0009779981 (0) | 0.0004500466 (0.23) | 0.0011716019 (0.01) | 0.0003204781 (0.36) | -0.003363325 (0.06) | |
| Poverty Income Ratio | -0.002118725 (0.69) | -0.003268413 (0) | -0.000279512 (0.8) | -0.00551787 (0) | -0.00111354 (0.43) | -0.003278765 (0.61) | |
| Log10 of Body Mass Index | 0.2108936607 (0.05) | 0.0491633032 (0) | -0.073973343 (0.01) | 0.101456823 (0) | 0.0675861483 (0) | 0.3308218629 (0) | |
| Log10 of Serum Albumin | 0.3565304989 (0.09) | 0.2541341853 (0) | -0.088252294 (0.2) | 0.2911937567 (0) | -0.058409572 (0.47) | -0.533308716 (0.14) | |
| Lg10 of Blood Lead | 0.0617500552 (0.02) | -0.008514174 (0.08) | -0.015141522 (0.13) | -0.006632611 (0.31) | -0.010870387 (0.22) | 0.0346090971 (0.35) | |
| NHANES survey cycle | -0.005324027 (0.51) | -0.003272757 (0.21) | 0.0118291574 (0) | 0.0015936298 (0.64) | -0.006303805 (0.06) | 0.000885978 (0.95) | |
| R2 in percent | 6.0 | 30.1 | 6.3 | 20.8 | 4.2 | 5.3 | |
| Female: IOD* | Use other drugs | -0.019199135 (0.55) | -0.002866774 (0.63) | 0.0082121054 (0.25) | -0.000557795 (0.97) | 0.0236065558 (0.02) | 0.0578299402 (0.18) |
| Fasting in hours | 0.0075027757 (0.03) | 0.001333764 (0) | 0.0002278611 (0.65) | 0.0004716519 (0.47) | 0.0007126796 (0.27) | 0.0002878735 (0.88) | |
| Poverty Income Ratio | -0.002890589 (0.68) | -0.002455487 (0.09) | -0.001547872 (0.32) | -0.006217204 (0) | -0.004619988 (0.01) | -0.007612611 (0.31) | |
| Log10 of Body Mass Index | 0.2399973248 (0.03) | 0.0517147882 (0.01) | -0.024946026 (0.34) | 0.0909759416 (0.03) | 0.096691019 (0.01) | 0.0306783316 (0.84) | |
| Log10 of Serum Albumin | 0.0455124368 (0.88) | 0.1736607624 (0.02) | -0.06170066 (0.45) | -0.065987868 (0.6) | -0.378424338 (0) | -0.12641695 (0.81) | |
| Lg10 of Blood Lead | 0.0611458809 (0.21) | -0.005627128 (0.57) | 0.0029226235 (0.81) | -0.033757165 (0.01) | -0.003164823 (0.81) | 0.0526994513 (0.43) | |
| NHANES survey cycle | -0.009394394 (0.56) | -0.002042453 (0.33) | 0.0146301173 (0) | -0.001900373 (0.55) | -0.008318777 (0.04) | 0.0067406461 (0.72) | |
| Premenarche | 0.1650352097 (0.02) | 0.0388657006 (0.01) | -0.022047273 (0.26) | 0.076279679 (0) | -0.046544845 (0.01) | 0.0958813162 (0.33) | |
| Menopause | 0.0567437982 (0.1) | -0.011683835 (0.05) | 0.0091105501 (0.28) | 0.0005254126 (0.96) | 0.003380469 (0.76) | 0.0252302102 (0.56) | |
| No of live births | -0.011717488 (0.15) | 0.0000479555 (0.97) | -0.002352227 (0.14) | -0.002429194 (0.31) | 0.0000927245 (0.96) | -0.008791034 (0.43) | |
| R2 in percent | 9.1 | 16.6 | 5.1 | 9.2 | 13.3 | 8.5 | |
| Female: IOR* | Use other drugs | 0.0121621155 (0.46) | -0.021035976 (0) | 0.002202594 (0.67) | -0.031848284 (0) | -0.000337082 (0.96) | 0.0063424389 (0.86) |
| Fasting in hours | 0.0060879619 (0) | 0.0012754254 (0) | 0.0004620015 (0.24) | 0.0014080414 (0) | 0.0001018241 (0.82) | 0.0005962346 (0.82) | |
| Poverty Income Ratio | 0.0030432476 (0.51) | -0.00368989 (0) | -0.000011409 (0.99) | -0.005365296 (0.02) | -0.000443187 (0.77) | -0.008612939 (0.26) | |
| Log10 of Body Mass Index | 0.377353859 (0) | 0.0705398018 (0) | -0.04174673 (0.04) | 0.0879106429 (0) | 0.0490881087 (0.01) | 0.1122607097 (0.4) | |
| Log10 of Serum Albumin | 0.2849512363 (0.39) | 0.1792830379 (0) | -0.08458671 (0.21) | -0.039605998 (0.69) | -0.411087258 (0) | -0.365461581 (0.33) | |
| Lg10 of Blood Lead | 0.0239281375 (0.49) | -0.009003318 (0.17) | 0.0091433572 (0.23) | -0.022773137 (0.08) | 0.003635171 (0.76) | -0.037406285 (0.67) | |
| NHANES survey cycle | 0.0043626117 (0.62) | -0.003190543 (0.13) | 0.0130269123 (0) | 0.0055692255 (0.2) | -0.00359465 (0.36) | 0.0006056034 (0.98) | |
| Premenarche | 0.2020825192 (0) | 0.051894233 (0) | -0.014187607 (0.4) | 0.0717723245 (0) | -0.033760292 (0.06) | -0.021924191 (0.85) | |
| Menopause | 0.0414536832 (0.11) | -0.001923664 (0.67) | 0.004842686 (0.46) | -0.002008668 (0.81) | -0.002995773 (0.72) | 0.0468999028 (0.28) | |
| No of live births | -0.001967319 (0.67) | -0.00334126 (0) | -0.000483147 (0.65) | -0.002535476 (0.07) | -0.000195662 (0.89) | 0.0105347204 (0.22) | |
| R2 in percent | 9.8 | 22.6 | 5.7 | 14.1 | 5.9 | 6.8 |
*IOD = Iodine Deficient or urine iodine < 100 ng/mL; IOR=Iodine Replete or urine iodine ≥ 100 ng/mL.