Table 1: General andbiochemical features of individuals participated in the study.
|
HC |
PD |
Gr A |
Gr B |
Gr C |
Gr D |
GrT |
P |
HbA1c Level (%) |
HbA1c < 5.7 |
5.7 ≤ HbA1c ≤ 6.4 IFG/IGT. IFG + IGT |
HbA1c ≤ 6.4 |
6.5 ≤ HbA1c ≤ 7.9 |
8.0 ≤ HbA1c ≤ 9.9 |
10.0 ≤ HbA1c |
|
|
Number |
24 (%14.2) |
28 (%16.5) |
29 (%17.1) |
30 (%17.7) |
29 (%17.1) |
29 (%17.1) |
169 |
- |
Gender (M/F) |
13/11 |
15/13 |
15/14 |
16/14 |
14/15 |
15/14 |
88/81 |
- |
Age (year) |
47.9 ± 5.75 |
52.1 ± 8.63 |
58.1 ± 9.22 |
56.2 ± 9.55 |
56.0 ± 7.60 |
57.1 ± 8.89 |
54.8 ± 8.98 |
0.001 |
BMI (kg/m2) |
27.2 ± 3.11 |
32.1 ± 5.77 |
32.8 ± 5.47 |
33.8 ± 5.51 |
34.8 ± 5.25 |
35.6 ± 5.85 |
32.9 ± 5.83 |
0.001 |
WHR (cm)* |
0.92 ± 0.07 |
0.96 ± 0.04 |
0.98 ± 0.59 |
0.98 ± 0.06 |
0.97 ± 0.06 |
1.00 ± 0.05 |
0.97 ± 0.06 |
0.001 |
HbA1c (NGSP) (%) |
5.09 ± 0.17 |
5.73 ± 0.45 |
5.87 ± 0.34 |
7.01 ± 0.45 |
8.86 ± 0.65 |
11.31 ± 1.14 |
7.39 ± 2.24 |
0.001 |
FBG (mg/dl) |
84 ± 5.4 |
103 ± 8.7 |
116 ± 17.3 |
138 ± 17.7 |
182 ± 40.1 |
264 ± 54.4 |
150 ± 67.4 |
0.001 |
PPG (mg/dl) |
88 ± 10.5 |
123 ± 30.7 |
131 ± 41.0 |
197 ± 44.2 |
248 ± 76.5 |
327 ± 117.8 |
190 ± 103.5 |
0.001 |
FI (μU/ml) |
7.9 ± 4.4 |
14.4 ± 7.3 |
15.0 ± 8.1 |
17.9 ± 10.5 |
16.1 ± 14.6 |
13.9 ± 8.4 |
14.4 ± 9.9 |
0.001 |
HOMA-IR index |
1.65 ± 0.92 |
3.72 ± 2.15 |
4.38 ± 2.36 |
6.29 ± 3.77 |
7.45 ± 9.46 |
9.06 ± 6.05 |
5.60 ± 5.65 |
0.001 |
FCP (ng/ml) |
1.36 ± 0.52 |
2.38 ± 0.69 |
2.26 ± 0.92 |
2.46 ± 1.17 |
2.12 ± 1.24 |
2.15 ± 1.28 |
2.15 ± 1.07 |
0.001 |
CRP (mg/l) |
2.0 ± 0.24 |
2.8 ± 2.4 |
3.0 ± 2.2 |
3.8 ± 2.2 |
5.7 ± 4.4 |
8.3 ± 8.8 |
4.3 ± 4.8 |
0.001 |
UA (mg/dl) |
4.5 ± 0.9 |
5.2 ± 1.5 |
5.5 ± 1.2 |
5.1 ± 2 |
4.6 ± 1.7 |
4.1 ± 1.4 |
4.8 ± 1.6 |
0.002 |
Crn (mg/dl) |
0.76 ± 0.15 |
0.82 ± 0.17 |
0.72 ± 0.14 |
0.76 ± 0.18 |
0.71 ± 0.17 |
0.70 ± 0.19 |
0.74 ± 0.17 |
0.102 |
MAU (mg) |
5.95 ± 4.09 |
17.8 ± 56.4 |
29.8 ± 57.1 |
46.8 ± 65.9 |
65.6 ± 94.4 |
53.4 ± 88.2 |
37.8 ± 70.8 |
0.001 |
Tcol (mg/dl)* |
176 ± 41 |
188 ± 36 |
195 ± 39 |
212 ± 53 |
193 ± 43 |
192 ± 34 |
193 ± 2 |
0.072 |
HDL-c (mg/dl) |
51 ± 14 |
42 ± 9 |
42 ± 7 |
43 ± 9 |
40 ± 10 |
39 ± 10 |
43 ± 10 |
0.009 |
LDL-c (mg/dl) |
93 ± 40 |
110 ± 34 |
117 ± 30 |
132 ± 48 |
95 ± 44 |
90 ± 47 |
107 ± 43 |
0.014 |
TG (mg/dl) |
123 ± 108 |
168 ± 97 |
169 ± 81 |
211 ± 130 |
297 ± 523 |
295 ± 306 |
214 ± 270 |
0.001 |
TAC (mmol Trolox eq.) |
0.75 ± 0.07 |
0.67 ± 0.07 |
0.65 ± 0.08 |
0.70 ± 0.07 |
0.65 ± 0.08 |
0.70 ± 0.06 |
0.68 ± 0.08 |
0.001 |
TOS (μmol H2O2 ) |
23.2 ± 2.4 |
26 ± 4.3 |
25.6 ± 0.6 |
27.1 ± 4.4 |
26.8 ± 5.3 |
27.7 ± 4.5 |
26.2 ± 4.4 |
0.004 |
OSI |
31 ± 5.2 |
39.3 ± 7.2 |
39.7 ± 8 |
39.3 ± 8.7 |
41.9 ± 11.5 |
39.8 ± 7.8 |
38.7 ± 8.9 |
0.001 |
HC: Healthy Control; PD: Prediabet; Gr A: Group A ; Gr B: Group B; Gr C: Group C; Gr D: Group D; Gr T: Group Total; BMI: Body Mass Index; WHR: Waist-Hip Ratio; HbA1c: Glycosilated hemoglobin; FBG: Fasting Blood Glucose; PPG: Post Prandial Glucose; FI: Fasting Insulin; HOMA-IR: Homeostatic Model of Assessment-Insulin Resistance; FCP: Fasting C-Peptide; CRP: C-Reactive Protein; Crn: Creatinine; UA: Uric Acid; MAU: Microalbuminuria; T col: Total Cholesterol; HDL-c: High-Density Lipoprotein; LDL-c: Low-Density Lipoprotein; TG: Triglyceride; TAC: Total Antioxidant Capacity; TOS: Total Oxidative State; OSI: Oxidative Stress Index Data : Were expressed as mean ± SD; p values (*) oneway ANOVA. other data were calculated by Kruskal Walls tests