Table 1: In vitro antifungal susceptibility of Candida auris and Candida glabarta strains to Echinocandins and *Posaconazole.
|
|
Minimal Fungicidal Concentration (MFC) (μg/ml) |
Inhibitory concentration (μg/ml) |
|||||
Origin |
C. auris strains |
Caspofungin |
Micafungin |
Anidulafungin |
Posaconazole |
Caspofungin |
Micafungin |
Anidulafungin |
|
|
MFC |
MFC |
MFC |
IC* |
IC90% |
IC90% |
IC90% |
Japan |
CDC 0381 |
0.038 |
0.028 |
0.028 |
71%, 0.78 |
0.016 |
0.014 |
0.0135 |
South Asia |
CDC 0382 |
> 32 |
0.028 |
0.032 |
64%, 0.78 |
> 32 |
0.014 |
0.02 |
South Africa |
CDC 0383 |
> 32 |
> 32 |
> 32 |
60%, 0.39 |
> 32 |
> 32 |
> 32 |
South Africa |
CDC 0384 |
> 32 |
> 32 |
> 32 |
61%, 0.78 |
> 32 |
> 32 |
> 32 |
Venezuala |
CDC 0385 |
> 32 |
0.0625 |
0.0625 |
63%, 0.09 |
> 32 |
0.034 |
0.043 |
Venezuala |
CDC 0386 |
> 32 |
0.125 |
0.0612 |
65%, 0.78 |
> 32 |
0.055 |
0.0335 |
Pakistan |
CDC 0387 |
> 32 |
0.083 |
0.75 |
53%, 0.78 |
> 32 |
0.42 |
0.24 |
Pakistan |
CDC 0388 |
> 32 |
0.0625 |
0.032 |
79%, 0.19 |
> 32 |
0.0145 |
0.027 |
South Asia |
CDC 0389 |
> 32 |
0.032 |
0.032 |
70%, 0.19 |
> 32 |
0.016 |
0.024 |
South Asia |
CDC 0390 |
> 32 |
0.028 |
0.028 |
67%, 0.097 |
0.14 |
0.014 |
0.0145 |
|
C. glabrata 0317 |
> 32 |
0.03125 |
0.25 |
39% > 12.5 |
0.9 |
0.025 |
0.225 |
GM# |
|
> 32 |
0.056 ± 0.035 |
0.13 ± 0.25 |
0.49 ± 0.31 |
> 32 |
0.025 ± 0.016 |
0.05 ± 0.08 |
MIC50 |
|
ND |
0.028-0.032 |
0.028-0.032 |
0.09-0.39 |
ND |
0.014-0.016 |
0.014-0.016 |
MIC90 |
|
ND |
0.125 |
0.75 |
0.78 |
ND |
0.055 |
0.24 |
**CLSI-MIC50 |
|
0.016 |
ND |
0.125 |
0.125 |
|||
**CLSI-MIC90 |
0.125 |
ND |
0.5 |
0.5 |
*-Inhibition 53-79%, **-CLSI based tentative cutoff breakpoint of susceptibility for C. auris strains as reported by Arendrup, et al. 2017. #Geometric mean ± S.D. The values of the resistant strains (> 32 µg/ml, gray cell) are not included.