Table 1: In vitro antifungal susceptibility of Candida auris and Candida glabarta strains to Echinocandins and *Posaconazole.

 

 

Minimal Fungicidal Concentration (MFC) (μg/ml)

Inhibitory concentration (μg/ml)

Origin

C. auris strains

Caspofungin

Micafungin

Anidulafungin

Posaconazole

Caspofungin

Micafungin

Anidulafungin

 

 

MFC

MFC

MFC

IC*

IC90%

IC90%

IC90%

Japan

CDC 0381

0.038

0.028

0.028

71%, 0.78

0.016

0.014

0.0135

South Asia

CDC 0382

> 32

0.028

0.032

64%, 0.78

> 32

0.014

0.02

South Africa

CDC 0383

> 32

> 32

> 32

60%, 0.39

> 32

> 32

> 32

South Africa

CDC 0384

> 32

> 32

> 32

61%, 0.78

> 32

> 32

> 32

Venezuala

CDC 0385

> 32

0.0625

0.0625

63%, 0.09

> 32

0.034

0.043

Venezuala

CDC 0386

> 32

0.125

0.0612

65%, 0.78

> 32

0.055

0.0335

Pakistan

CDC 0387

> 32

0.083

0.75

53%, 0.78

> 32

0.42

0.24

Pakistan

CDC 0388

> 32

0.0625

0.032

79%, 0.19

> 32

0.0145

0.027

South Asia

CDC 0389

> 32

0.032

0.032

70%, 0.19

> 32

0.016

0.024

South Asia

CDC 0390

> 32

0.028

0.028

67%, 0.097

0.14

0.014

0.0145

 

C. glabrata 0317

> 32

0.03125

0.25

39% > 12.5

0.9

0.025

0.225

GM#

 

> 32

0.056 ± 0.035

0.13 ± 0.25

0.49 ± 0.31

> 32

0.025 ± 0.016

0.05 ± 0.08

MIC50

 

ND

0.028-0.032

0.028-0.032

0.09-0.39

ND

0.014-0.016

0.014-0.016

MIC90

 

ND

0.125

0.75

0.78

ND

0.055

0.24

**CLSI-MIC50

 

0.016

ND

0.125

0.125

**CLSI-MIC90

0.125

ND

0.5

0.5

*-Inhibition 53-79%, **-CLSI based tentative cutoff breakpoint of susceptibility for C. auris strains as reported by Arendrup, et al. 2017. #Geometric mean ± S.D. The values of the resistant strains (> 32 µg/ml, gray cell) are not included.