Table 2: In vitro antifungal susceptibility (fungicidal ~MIC100) of Candida auris and Candida glabrata to Amphotericin-B (AmB) deoxycholate, and liposomal preparations of Amphotericin-B.

Origin

Candida strains

AmB-deoxycholate

Liposomal AmB

Amfocare™

AmBisome®

FUNGISOME®,

Japan

C. auris CDC 0381

0.25

2

0.125

South Asia

C. auris CDC 0382

0.21

2

0.25

South Africa

C. auris CDC 0383

0.5

4

0.5

South Africa

C. auris CDC 0384

0.5

8

0.5

Venezuala

C. auris CDC 0385

1

16

0.5

Venezuala

C. auris CDC 0386

32

> 32

0.83

Pakistan

C. auris CDC 0387

32

32

0.25

Pakistan

C. auris CDC 0388

0.33

> 32

1

South Asia

C. auris CDC 0389

1

> 32

1.33

South Asia

C. auris CDC 0390

0.5

> 32

0.83

N/A

C. glabrata CDC 0317

0.25

1

0.125

GM#

 

0.53 ± 0.31 (n = 8)

6.4 ± 5.9 (n = 5)

0.6 ± 0.4 (n = 10)

MIC50

 

0.25-0.5

 

0.125-0.25

MIC90

 

32

32

1.3

**CLSI-50

 

0.5

N/A

**CLSI-90

 

2

N/A: Not available: **CLSI method-based tentative cutoff breakpoint of susceptibility for C. auris as reported by Arendrup, et al. 2017. #Geometric mean ± S.D., the Values of resistant strains (gray cell ≥ 32) are not included.