Table 2: In vitro antifungal susceptibility (fungicidal ~MIC100) of Candida auris and Candida glabrata to Amphotericin-B (AmB) deoxycholate, and liposomal preparations of Amphotericin-B.
Origin |
Candida strains |
AmB-deoxycholate |
Liposomal AmB |
|
Amfocare™ |
AmBisome® |
FUNGISOME®, |
||
Japan |
C. auris CDC 0381 |
0.25 |
2 |
0.125 |
South Asia |
C. auris CDC 0382 |
0.21 |
2 |
0.25 |
South Africa |
C. auris CDC 0383 |
0.5 |
4 |
0.5 |
South Africa |
C. auris CDC 0384 |
0.5 |
8 |
0.5 |
Venezuala |
C. auris CDC 0385 |
1 |
16 |
0.5 |
Venezuala |
C. auris CDC 0386 |
32 |
> 32 |
0.83 |
Pakistan |
C. auris CDC 0387 |
32 |
32 |
0.25 |
Pakistan |
C. auris CDC 0388 |
0.33 |
> 32 |
1 |
South Asia |
C. auris CDC 0389 |
1 |
> 32 |
1.33 |
South Asia |
C. auris CDC 0390 |
0.5 |
> 32 |
0.83 |
N/A |
C. glabrata CDC 0317 |
0.25 |
1 |
0.125 |
GM# |
|
0.53 ± 0.31 (n = 8) |
6.4 ± 5.9 (n = 5) |
0.6 ± 0.4 (n = 10) |
MIC50 |
|
0.25-0.5 |
|
0.125-0.25 |
MIC90 |
|
32 |
32 |
1.3 |
**CLSI-50 |
|
0.5 |
N/A |
|
**CLSI-90 |
|
2 |
N/A: Not available: **CLSI method-based tentative cutoff breakpoint of susceptibility for C. auris as reported by Arendrup, et al. 2017. #Geometric mean ± S.D., the Values of resistant strains (gray cell ≥ 32) are not included.