Properties

Amphotericin-B deoxycholate

Liposomal Amphotericin-B

Amfocare™ (BPRL) 50 mg/10 ml

AmBisome® (Gilead) 50 mg/10 ml

FUNGISOME (Lifecare Innovations 1 mg/ml 10 ml, 50 ml

Particle

Micelle

Liposome-small unilamellar vesicles (SUV)

Liposome: multilamellar vesicles MLV--- > SUV

Size (nm)

25

77.8 (60-80)

2743-3454-- > 20-200

Amphoterician B (Mol%)

34

10

1

Carrier

Deoxycholate

Liposome (^*DSPG: ^**HSPC: Cholesterol)

Liposome (HSOC:Cholesterol)

Carrier: Amphotericin B

2:01

(0.8:2:1):0.4(7:1::Lipid:drug)

(7:3):0.22(45:1::Lipid:drug)

Diateroryl phosphatidyl glycerol (DSPG)

84

Hydrogenated Soy Phosphatidyl choline (HSPC)

213

31.5

Cholesterol

52

13.5

Sucrose

900

α-tocopherol

0.64

Disodium succinate hexahydrate

27

Vehicle

PBS

Distilled water

Normal saline (0.9% Nacl)

Sonication

Not required

Not required

45 min

Nephrotoxicity

34-60%

10-20%

Negligible or not detected

Antifungal Clinical trials

Several-See ref. [41]

Several-See ref. [41,42,78]

Limited see ref- [41,45,48.73,75]

Relative Cost/Stability

Not expensive/one week

Expensive/72h

Less expensive/1 year 4 °C. If unused Resonication after 24 hour

Availability/usage

Universal

Universal

Limited to certain countries. Available where C. auris is most prevalent

References

[41,44,47]

[40-42, 46,78]

[41,45,48,73,75]