No.

Author(s)

Year

Title of the Study

Study Design

Key Findings

1

Carbajal, et al. [1]

2008

Epidemiology and treatment of painful procedures in neonates in intensive care units

Observational Study

Neonates in NICUs undergo numerous painful procedures, with inadequate analgesia.

2

Grunau, et al. [2]

2006

Long-term consequences of pain in human neonates

Review

Pain in neonates can have long-term developmental and behavioral consequences.

3

Stevens, et al. [3]

2013

Sucrose for analgesia in newborn infants undergoing painful procedures

Systematic Review

Sucrose is effective as a non-pharmacological analgesic for painful procedures in neonates.

4

Anand and Hall, [4]

2006

Controversies in neonatal pain: Analyzing the evidence for a pain-free start in life

Review

Neonates experience pain, and effective management is crucial for their well-being.

5

Johnston, et al. [5]

2017

Pain in Canadian NICUs: Have we improved over the past 12 years?

Observational Study

Improvement in pain management in NICUs over time, but gaps still exist.

6

Hall and Anand, [6]

2014

Pain management in newborns

Review

Comprehensive approaches are needed for effective neonatal pain management.

7

Olsson, et al. [7]

2016

Skin-to-skin contact reduces pain responses in premature infants during blood sampling

Experimental Study

Skin-to-skin contact effectively reduces pain responses in premature infants.

8

Johnston, et al. [8]

2011

Kangaroo mother care diminishes pain from heel lance in very preterm neonates

Crossover Trial

Kangaroo care reduces pain during procedures like heel lance in very preterm neonates.

9

Moher, et al. [9]

2009

PRISMA: Preferred reporting items for systematic reviews and meta-analyses

Methodological Framework

Standardizes reporting for systematic reviews and meta-analyses.

10

Palmer and Anderson, [10]

2017

Paracetamol in pediatrics: Pharmacokinetics, efficacy, safety

Review

Paracetamol is effective and safe for pain management in neonates, though liver injury concerns exist.

11

Anand, et al. [11]

2019

Neonatal pain and its long-term effects

Review

Neonatal pain can lead to long-term neurodevelopmental and behavioral issues.

12

Harrison, et al. [12]

2017

Breastfeeding for procedural pain in neonates

Systematic Review

Breastfeeding effectively reduces pain in neonates during procedures.

13

Shah, et al. [13]

2012

Breastfeeding or breast milk for procedural pain in neonates

Systematic Review

Breastfeeding or breast milk is effective for reducing procedural pain in neonates.

14

Peng, et al. [14]

2018

Effect of facilitated tucking on pain responses during venipuncture in preterm infants

Experimental Study

Facilitated tucking is effective in reducing pain responses during venipuncture in preterm infants.

15

Johnston, et al. [15]

2017

Non-pharmacological interventions for managing pain in neonates

Systematic Review

Non-pharmacological interventions, including skin-to-skin contact and breastfeeding, are effective.

16

Harrison, et al. [16]

2017

Paracetamol for postoperative pain management in neonates

Experimental Study

Paracetamol is effective for postoperative pain management in neonates.

17

Benoit, et al. [17]

2009

Breastfeeding analgesia in infants: An updated systematic review

Systematic Review

Confirms the effectiveness of breastfeeding as an analgesic during painful procedures in infants.

18

Anand and Hickey, [18]

2013

Pain and its effects in the human neonate and fetus

Review

Neonates and fetuses experience pain, which can have immediate and long-term physiological effects.