Table 3: Vasoactive drug administration.
|
Parameter |
Basal* |
AoXC |
AoUC |
p |
|
No vasoactive drugs (n = 19) |
|
|
|
|
|
MAP (mmHg) |
83 (14.5) |
80 (6.3) |
82 (14.7) |
0.5775 |
|
HR (bpm) |
60 (53÷70) |
59 (53÷65) |
63 (59÷68) |
0.7414 |
|
SV (ml) |
69 (46÷92)§ |
75 (55÷114) |
82 (45÷80)§ |
0.0327 |
|
CI (L/min/m2) |
1.0 (0.6÷1.5)§§ |
2.1 (1.1÷3.0) |
2.6 (2.0÷3.6)§§ |
0.0118 |
|
Ea-dyn |
1.2 (0.7-1.8) |
0.9 (0.6-1.3) |
1.00 (0.6÷1.5) |
0.0767 |
|
dP/dt (mmHg/sec) |
743(303÷1439) |
837 (380÷1242) |
702(370÷131) |
0.4595 |
|
Norepinephrine (n = 15) |
|
|
|
|
|
MAP (mmHg) |
85 (12.2) |
78 (11.1) |
77 (14.2) |
0.2035 |
|
HR (bpm) |
64 (9.2) |
56 (10.8) |
60 (11.6) |
0.0182# |
|
SV (ml) |
74 (21.7) |
83 (24.1) |
79 (21) |
0.6583 |
|
CI (L/min/m2) |
2.6 (0.91) |
2.5 (0.82) |
2.6 (0.7) |
0.6329 |
|
Ea-dyn |
1.1 (0.3) |
0.9 (0.2) |
0.9 (0.2) |
0.0023## |
|
dP/dt (mmHg/sec) |
763 (284.1) |
593 (211.1) |
676 (248.1) |
0.7012 |
|
Norepinephrine + Dobutamine (n = 6) |
|
|
|
|
|
MAP (mmHg) |
87.5 (10.0) |
74 (12.1) |
88 (9.4) |
0.0290¶ |
|
HR (bpm) |
67 (10.5) |
68 (26.2) |
77 (24.4) |
0.4822 |
|
SV (ml) |
58 (7.3) |
64 (9.8) |
66 (15.9) |
0.4104 |
|
CI (L/min/m2) |
1.9 (0.1) |
2 (0.3) |
2.4 (0.2) |
0.0035¶¶ |
|
Ea-dyn |
1.3 (0.3) |
1 (0.4) |
1.3 (0.3) |
0.0616 |
|
dP/dt (mmHg/sec) |
645 (309) |
555 (222) |
698 (389) |
0.4744 |
Data are listed as Mean and SD and as Median and IQR. One-way ANOVA test for comparison between Repeated Measures; Basal: 20-30 minutes after anesthesia induction; AoXC: 5 minutes after aortic clamping; AoUC: 5 minutes after aortic unclamping; *Before vasoactive drugs started and administered according the HPI protocol.