Study

Title

Design

Sample size

Country

Age

BMI

Intervention

Control

XIMEI WANG 2022

Safety and efficacy of Remimazolam besylate in patients undergoing colonoscopy: A multicentre, single-blind, randomized, controlled, phase Ⅲ trial

Multicentre, single-blind, randomized, controlled, phase III trial

477

China

Remimazolam: 44.3 (33.0-54.0); Propofol: 46.4 (37.5-56.0); (p = 0.095)

Remimazolam besylate: 22.82 (20.70-24.90) ; Propofol: 22.87 (21.10-24.60) (p = 0.843)

Remimazolam besylate

Propofol injection

SHAOHUI 2020

Effect of Remimazolam versus Propofol sedation on the quality of recovery after colonoscopy A randomised, controlled, noninferiority trial

Multicentered,

randomized, positive-controlled, phase III clinical trial

388

China

Remimazolam: 44.47 ± 11.67; Propofol: 44.43 ± 11.37; (p = 0.975)

Remimazolam: 23.19 ± 2.92; Propofol: 23.21 ± 2.84 (p = 0.953)

Remimazolam tosylate

Propofol

XIANWEN LIU 2023

The Efficacy and Safety of Remimazolam Tosilate versus Etomidate-Propofol in Elderly Outpatients Undergoing Colonoscopy: A Prospective, Randomized, Single-Blind, Non-Inferiority Trial

Single-center, prospective, randomized, single blind, non-inferiority trial

260

China

Remimazolam: 68.87 ± 2.58; Propofol: 69.12 ± 2.75; (p = 0.476)

Remimazolam: 25.35 ± 2.07; Propofol: 24.75 ± 2.16; (p = 0.073)

Remimazolam tosylate

Etomidade-propofol

YUSHEN YAO 2022

Discharge readiness after Remimazolam versus Propofol for colonoscopy A randomised, double-blind trial

Prospective, single-centre, randomised, double-blind, parallel-group, noninferiority clinical trial.

132

China

Remimazolam: 49 [41 to 56]; Propofol: 48 [39 to 56]; (p = 0.776)

Remimazolam: 22.4 [19.8 to 24.6]; Propofol: 22.0 [20.1 to 25.3]; (p = 0.562)

Remimazolam

Propofol

LULU GUO 2022

The efficacy and safety of Remimazolam tosylate versus Propofol in patients undergoing colonoscopy: A multicentered, randomized, positive-controlled, phase III clinical trial

Randomised, controlled, noninferiority trial

248

China

Remimazolam 48 [40 to 52] and Propofol 49 [41 to 55];

(p = 0.25)

Remimazolam 24.1 ± 2.5 (p = 0.48)

Remimazolam tosylate 5 mg

Propofol 1.5 mg kg1