Table 2: Summary of findings for primary and secondary outcomes.

N

Outcomes

Trials

n

I2 (%)

Effect model

MD/OR (95% CI)

p-value

1

Discharge

5

1505

82

REM

-0.09 [-1.11, 0.93]

0.86

2

Injection pain

5

1505

63

REM

0.11 [0.05, 0.22]

< 0.00001

3

Fully alert

4

1293

83

REM

-3.09 [-38.16, 31.98]

0.86

4

Induction time

5

1505

96

REM

21.31 [9.95, 32.67]

0.0002

5

Hypotension

5

1505

67

REM

0.40 [0.26, 0.63]

<0.0001

6

Adverse events

3

1125

56

REM

0.53 [0.34, 0.83]

0.006

I2: Heterogeneity; MD: Mean Difference; OR: Odds Ratio; REM: Random Effect Model; CI: Confidence Interval