Ref

n total (R/C)

Rate of nausea and/or vomiting*

n

Willingness to repeat, n

Recall

n

Satisfaction with sedation

Pain, working conditions, comfort.

Author/physician favours

Patient Favours

 

 

R

C

P-value

R

C

R

C

R

C

No diff.

R

C

No diff.

Remifentanil vs. Propofol

Lee et al. [17]

50 (25/32)

NA

NA

 

NA

NA

NA

NA

NA

NA

 

NA

NA

 

Bouvet et al. [19]

77 (41/36)

14

0

ns

NA

NA

NA

NA

 

 

X

 

 

x

Krenn et al. [20]

60 (30/30)

NA

NA

 

NA

NA

NA

NA

NA

NA

 

 

 

x

Holas et al. [22]

30 (15/15)

4

0

<0.027

NA

NA

NA

NA

 

 

X

 

 

x

Lena et al. [26]

40 (20/20)

2

0

ns

NA

NA

NA

NA

 

 

X

 

 

x

Zhang et al. [29]

36 (18/18)

NA

NA

 

18

17

18

7

X

 

 

 

 

x

Lallo et al. [30]

60 (30/30)

0

0

ns

NA

NA

26

14

X

 

 

 

 

x

Ferraro et al. [31]

60 (30/30)

5

3

ns

NA

NA

NA

NA

X

 

 

NA

NA

 

Girard et al. [34]

40 (20/20)

NA

NA

 

NA

NA

NA

NA

NA

NA

 

NA

NA

 

Sub Total,

n

460

(229/231)

25/136

3/131

<0.005

18/18

17/17

44/45

38/45

3/6

0/6

3/6

0/6

0/6

6/6

%

 

18.4

2.3

 

100

100

98

47

 

 

 

 

 

 

Remifentanil vs. Midazolam + opioid

Avramov et al. [3]

81 (19/62)

10

21

ns

17

56

19

24

NA

NA

 

 

 

X

Bonfreschi et al. [16]

50(25/25)

0

0

ns

NA

NA

NA

NA

X

 

 

NA

NA

 

Fanti et al. [18]

90 (60/30)

0

4

0.032

57

30

59

30

 

 

X

 

 

X

Lier et al. [23]

78 (38/40)

NA

NA

 

NA

NA

NA

NA

NA

NA

 

X

 

 

Puchner et al. [24]

74 (37/37)

NA

NA

 

NA

NA

6

0

X

 

 

 

 

X

Manolaraki et al. [25]

116 (60/56)

2

3

ns

60

56

NA

NA

 

 

X

 

 

X

Ferraro et al. [31]

60 (30/30)

7

6

ns

NA

NA

NA

NA

X

 

 

NA

NA

 

Sub Total,

n

549

(269/280)

19/172

34/187

<0.005

134/139

142/148

84/116

54/129

3/5

0/5

2/5

1/5

0/5

4/5

%

 

9.8

16.7

 

96

96

72

42

 

 

 

 

 

 

Remifentanil vs. opioid

Orbach-zinger et al. [12]

30 (14/16)

6

3

ns

NA

NA

NA

NA

 

 

X

 

 

X

Cortinez et al. [27]

44 (22/22)

3

9

ns

NA

NA

NA

NA

NA

NA

 

NA

NA

 

Akgl et al. [35]

80 (40/40)

NA

NA

 

NA

NA

NA

NA

 

 

X

 

 

X

Sub Total,

n

154 (76/78)

9/36

12/38

0.611

 

 

 

 

0/2

0/2

2/2

0/2

0/2

2/2

%

 

25.0

31.6

 

 

 

 

 

 

 

 

 

 

 

Remifentanil vs. Propofol + Remifentanil

Joo et al. [13]

120 (60/60)

16

5

0.016

51

53

NA

NA

 

 

X

 

X

 

Holas et al. [22]

30 (15/15)

4

0

<0.027

NA

NA

NA

NA

 

X

 

 

 

X

Sub Total,

n

150 (75/75)

20/75

5/75

0.002

51/60

53/60

 

 

0/2

1/2

1/2

0/2

1/2

1/2

%

 

26.7

6.7

 

85

88

 

 

 

 

 

 

 

 

Remifentanil vs. TIVA: Propofol+Remifentanil

Majholm et al.[15]

91 (49/42)

11

2

0.016

45

27

NA

NA

 

 

X

X

 

 

%

 

22.4

4.8

 

92

65

 

 

 

 

 

 

 

 

Remifentanil vs. Dexmedetomidine

Hu et al. [14]

40 (20/20)

NA

NA

 

NA

NA

13

6

 

X

 

 

X

 

Total, n

1444

(718/726)

84/490

56/489

p=0.013

248/266

239/267

141/181

98/194

6/17

2/17

9/17

2/17

2/17

13/17

%

 

16.5

10.2

 

93.2

89.5

77.9

50.5

35.2

11.8

53.0

11.8

11.8

76.5

Table 3: Postoperative nausea and vomiting and satisfaction