Table 1: Pharmacokinetic parameters after
intramuscular injection of SUF and SUFHP-β-CD complex in
rabbits and pigs (10 µg.kg-1). Data expressed as mean (± SD) (n =
5-6/group).
Pharmacokinetic
Parameters (Mean ± SD) |
Phase I |
Phase II |
||
SUF |
SUFHP-β- CD |
SUF |
SUFHP-β-
CD |
|
Cmax (ng.mL-1) |
7.82 ± 4.75 |
1.50 ± 1.17* |
265.97
± 297.22 |
11.29
± 8.64● |
Tmax (h) |
0.41 ± 0.30 |
0.29 ± 0.10 |
0.35
± 0.13 |
0.45
± 0.20 |
AUC0-480 (ng-h.mL-1) |
10.86 ± 4.44 |
2.70 ± 1.83** |
215.11
± 179.71 |
13.47
± 15.30● |
AUC0-∞ (ng-h.mL-1) |
12.70 ± 4.38 |
4.77 ± 2.53** |
217.47
± 178.51 |
17.12
± 22.59● |
t ½ beta (h) |
3.23 ± 2.08 |
5.33 ± 2.55 |
1.71
± 0.79 |
2.89
± 2.07 |
Vd (L) |
12.89 ± 10.42 |
89.57 ± 75.67* |
5.81
± 6.37 |
95.73
± 58.70●● |
Note: Statistical Analysis: Phase I- SUF vs. SUFHP-β-CD: p < 0.01[**], p < 0.05[*], p > 0.05
[not significant];
Phase II- SUF
vs. SUFHP-β-CD: p < 0.01[●●], p
< 0.05[●], p > 0.05 [not significant]. Cmax- Maximum Plasma Concentration; Tmax:
Time to reach maximum plasma concentration; AUC: Areas under the curves; t
½: Half life
of elimination; Vd: Volume
of distribution.