Table 1: Pharmacokinetic parameters after intramuscular injection of SUF and SUFHP-β-CD complex in rabbits and pigs (10 g.kg-1). Data expressed as mean ( SD) (n = 5-6/group).

Pharmacokinetic Parameters (Mean SD)

Phase I

Phase II

SUF

SUFHP-β- CD

SUF

SUFHP-β- CD

Cmax (ng.mL-1)

7.82 4.75

1.50 1.17*

265.97 297.22

11.29 8.64

Tmax (h)

0.41 0.30

0.29 0.10

0.35 0.13

0.45 0.20

AUC0-480 (ng-h.mL-1)

10.86 4.44

2.70 1.83**

215.11 179.71

13.47 15.30

AUC0-∞ (ng-h.mL-1)

12.70 4.38

4.77 2.53**

217.47 178.51

17.12 22.59

t beta (h)

3.23 2.08

5.33 2.55

1.71 0.79

2.89 2.07

Vd (L)

12.89 10.42

89.57 75.67*

5.81 6.37

95.73 58.70●●

 

Note: Statistical Analysis: Phase I- SUF vs. SUFHP-β-CD: p < 0.01[**], p < 0.05[*], p > 0.05 [not significant];

Phase II- SUF vs. SUFHP-β-CD: p < 0.01[●●], p < 0.05[], p > 0.05 [not significant]. Cmax- Maximum Plasma Concentration; Tmax: Time to reach maximum plasma concentration; AUC: Areas under the curves; t : Half life of elimination; Vd: Volume of distribution.