Table 1: Causes of thrombocytopenia during pregnancy and relative frequencies.
Thrombocytopenia Etiologies during Pregnancy |
Pregnancy-related |
Gestational Thrombocytopenia, 70-80% |
Thrombocytopenia in systemic disease |
- Preeclampsia, 15-20% |
- HELLP syndrome, < 1% |
Non-pregnancy related |
Congenital |
-Von Willebrand syndrome, < 1% |
-Hereditary thrombocytopenia, < 1% |
Acquired|Immune mediated |
- Autoimmune thrombocytopenia, 1-4% |
- Systemic lupus erythematosus, < 1% |
- Antiphospholipid syndrome, < 1% |
- Drug-induced thrombocytopenia, < 1% |
Thrombotic thrombocytopenic purpura, hemolytic-uremic syndrome < 1% |
Acquired|Non-immune mediated |
Secondary thrombocytopenia associated with infectious disease (e.g. HIV, HCV, EBV) |
- Bone marrow diseases, < 1% |
- Poor nutrition, folate or vitamin B12 deficiency, < 1% |
- Hypersplenism, < 1% |