Thrombocytopenia Etiologies during Pregnancy

Pregnancy-related

Gestational Thrombocytopenia, 70-80%

Thrombocytopenia in systemic disease

- Preeclampsia, 15-20%

- HELLP syndrome, < 1%

Non-pregnancy related

Congenital

-Von Willebrand syndrome, < 1%

-Hereditary thrombocytopenia, < 1%

Acquired|Immune mediated

- Autoimmune thrombocytopenia, 1-4%

- Systemic lupus erythematosus, < 1%

- Antiphospholipid syndrome, < 1%

- Drug-induced thrombocytopenia, < 1%

Thrombotic thrombocytopenic purpura, hemolytic-uremic syndrome < 1%

Acquired|Non-immune mediated

Secondary thrombocytopenia associated with infectious disease (e.g. HIV, HCV, EBV)

- Bone marrow diseases, < 1%

- Poor nutrition, folate or vitamin B12 deficiency, < 1%

- Hypersplenism, < 1%