Table 2: Clark
classification of allergic adverse reactions.
Grade |
Clinical manifestations |
1. Mild |
Localized skin lesions (hives, rash, angioedema or
oral pruritus) |
2. Mild |
Generalized skin reactions |
3. Mild |
Grade 1 or 2 associating rhinoconjunctivitis
or gastrointestinal symptoms |
4. Moderate |
Difficulty breathing |
5. Severe |
Severe respiratory distress or systemic symptoms
(hypotension, loss of consciousness) |