Supplementary File 1: Naranjo ADR probability scale [9].
| S.No | Question | Yes | No | Don't know | Score |
| 1 | Are there previous conclusive reports on this reaction? | +1 | 0 | 0 | 1 |
| 2 | Did the adverse event appear after the suspected drug was administered? | +2 | -1 | 0 | 2 |
| 3 | Did the adverse reaction improve when the drug was discontinued, or a specific antagonist was administered? | +1 | 0 | 0 | 1 |
| 4 | Did the adverse reaction reappear when the drug was readministered? | +2 | -1 | 0 | 2 |
| 5 | Are there alternative causes (other than the drug) that could on their own have caused the reaction? | -1 | +2 | 0 | 2 |
| 6 | Did the reaction reappear when a placebo was given? | -1 | +1 | 0 | 0 |
| 7 | Was the drug detected in the blood (or other fluids) in concentrations known to be toxic? | +1 | 0 | 0 | 0 |
| 8 | Was the reaction more severe when the dose was increased, or less severe when the dose was decreased? | +1 | 0 | 0 | 0 |
| 9 | Did the patient have a similar reaction to the same or similar drug in any previous exposure? | +1 | 0 | 0 | 0 |
| 10 | Was the adverse event confirmed by any objective evidence? | +1 | 0 | 0 | 0 |
| Total | 8 points |