Table 2: MiRNAs reported up-regulated in glioblastoma samples.
Only miRNAs reported in at least 3 profiling reports were considered (for more information see Table 1). Studies performed on cell lines were not considered for miRNA profile. *Number of studies reporting the same regulation pattern for each miRNA (see Table 1). †In this study, authors obtained a down-regulation of selected miRNA. NA, Functional studies are not available in literature.

RNAs up-regulated in GBM	Number of profiling studies*	Functions	Targets validated in GBM	References
miR-21	15	Apoptosis	Caspases, PDCD4, p63, JMY, TOPORS, TP53BP2, HNRPK, TGFBR2/3, DAXX	[24,71,98,100]
		Invasion	RECK, TIMP3	[114]
		Cell cycle/ Tumor growth	hTERT, PTEN	[20,113]
miR-10b	7	Apoptosis	Bim, caspases, TP53, CYLD, FOXO3	[99,114]
		Invasion	HOXD10, NOTCH1, PAX6	[44,99]
		Cell cycle/Tumor growth	TFAP2C, p16, p21, PTCH1	[99,114]
		Angiogenesis	NOTCH1, CYLD, PAX6	[99]
miR-15b	5	Cell Cycle	CCNE1	[111]
miR-16	5	NA	NA	-
miR-25	6	Cell cycle/apoptosis	Mdm2, TSC1	[108]
miR-92b	5	Proliferation /invasion	NLK	[110]
miR-93	4	Proliferation/ Angiogenesis	Integrin-β8	[105]
miR-106b	4	Cell cycle/proliferation	RBL2, p21	[112]
miR-155	4	Proliferation	GABRA1	[103]
miR-210	4	NA	NA	-
miR-17-5p	3	DNA repair	Pold 2	[40]
		Proliferation	TGFBRII, SMAD4, CDKN1A, PTEN, E2F1	[102]
		Angiogenesis	CTGF	[104]
miR-106a	3	Proliferation/apoptosis	E2F1	[52] †
miR-148a	3	NA	NA	-
miR-196b	3	Proliferation	E2F1	[107]