Table 3: MiRNAs reported down-regulated in glioblastoma samples  
Only miRNAs reported in at least 3 profiling reports were considered (for more information see Table 1). Studies performed on cell lines were not considered for miRNA profile. ^ Five studies were focused on miR-128a. *Number of studies reporting the same regulation pattern for each miRNA (see Table 1). †In these studies, an up-regulation of selected miRNAs was observed. NA, Functional studies are not available in literature

MiRNAs down-regulated in GBM	Number of profiling studies*	Cellular Functions	Validated targets in GBM	References
miR-128^	8	Proliferation, self -renewal, cell cycle	ARP5, Bmi1, E2F3A, EGFR, PDGFRA, WEE1	[31,128,131,132]
		Angiogenesis	p70S6K1	[133]
miR-218	5	Migration/invasiveness	IKK-β, LEF1	[122,125]
		Apoptosis	ECOP	[129]
miR-132	5	NA	NA	-
miR-7	4	Proliferation	EGFR, IRS1, IRS2	[72]
		Invasiveness	FAK	[127]
miR-124	3	Migration/invasiveness	IQGAP1, LAMC1, ITGB1	[120]
		Cell cycle/proliferation	CDK6, pRB, CDK4,	[47,119]
miR-323	3	NA	NA	-
miR-221	4	Cell cycle	p27/KIP1, p57/KIP2	[80,82]†
		Apoptosis	NIAP, PUMA	[81,83]†
		Invasiveness	PTPμ	[78]†
miR-181b	3	Proliferation/invasivenes	IGF1R	[124]
miR-222	3	Cell cycle	p27/KIP1, p57/KIP2	[80,82]†
		Apoptosis	NIAP, PUMA	[81,83]†
		Invasiveness	PTPμ	[78]†
miR-31	3	Migration/Invasiveness	RDX	[130]
miR-138	3	Proliferation	Msi1	[126]
miR-181c	3	NA	NA	-
miR-379	3	NA	NA	-