Table 2:  Regions that showed significant structural differences between treatment-resistant depression (TRD) and healthy control groups.

 

 

 

MNI Coordinates

 

Cluster Size

Z-Statistic

X

Y

Z

Volume

 

 

 

 

 

Controls > TRD

 

 

 

 

 

L Hippocampus

290

7.00

-20

-24

-16

L Medial Orbitofrontal

27

4.25

-8

30

-26

Cortex

 

 

 

 

 

R Hippocampus

19

3.62

24

-40

6

R Hippocampus

7

3.24

35

52

29

TRD > Controls

 

 

 

 

 

n/a

 

 

 

 

 

Fractional Anisotropy (FA)

 

 

 

 

 

Controls > TRD

 

 

 

 

 

n/a

 

 

 

 

 

TRD > Controls

 

 

 

 

 

L Angular Bundle

8

4.41

-25

-28

-20

R Uncinate Fasciculus

3

4.00

39

10

-28

Mean Diffusivity (MD)

 

 

 

 

 

Controls > TRD

 

 

 

 

 

n/a

 

 

 

 

 

TRD > Controls

 

 

 

 

 

n/a

 

 

 

 

 

Mode of Anistropy (MO)

 

 

 

 

 

Controls > TRD

 

 

 

 

 

n/a

 

 

 

 

 

TRD > Controls

 

 

 

 

 

R Uncinate Fasciculus

5

4.57

40

9

-27