Group A | Group B | Group C | Total | ||
Localization | |||||
Abdominal | 4 | 31 | 11 | 46 | |
ORL | 1 | 8 | 2 | 11 | |
Cervical | 2 | 2 | 4 | ||
Bone | 3 | 3 | |||
Other / combination | 9 | 3 | 10 | ||
Results after COP | |||||
> 25% response | 48 | 15 | 63 | ||
< 25 % response | 2 | 1 | 3 | ||
Results after CYM/CYVE | |||||
CR | 37 | 14 | 51 | ||
Residual mass | Viable tumour | 7 | |||
Necrotic tissue | 6 | ||||
Primary treatment outcome | |||||
CR | 6 | 46 | 15 | 67 | |
PR | 0 | ||||
Resistant / progressive disease | 1 | 3 | 1 | 5 | |
Death due to disease | 7 | 1 | 8 | ||
Death due to toxicity | 2 | 1 | 3 | ||
Relapse | |||||
Local | 1 | 4 | 5 | ||
BM | 2 | 2 | |||
Local + BM ± CNS | 2 | 0 | |||
BM + CNS | 0 | ||||
CNS | 1 | 1 | |||
Survival rate | |||||
2- year OS | 100% | 83.1% | 86.7% | ||
2-year EFS | 85.7% | 81.1% | 81.3% |