The genotypic frequencies of twelve mutations in ten cardiovascular disease genes in coronary artery patients and healthy control groups.

Table 2: The genotypic frequencies of twelve mutations in ten cardiovascular disease genes in coronary artery patients and healthy control groups.

	Coronary artery patients				Healthy controls
Gene mutations	n	Homozygote Wild type	Heterozygote	Homozygote	N	Homozygote Wild type	Heterozygote	Homozygote Mutant	p value^*
	(Total)	n (%)	n (%)	Mutant	(Total)	n (%)	n (%)	n (%)
				n (%)
Factor V Leiden	27	26 (96.3)	1 (3.7)	0	8	8 (100)	0	0	0.581
Factor V (H1299R)	24	20 (83.3)	4 (16.7)	0	7	6 (85.7)	1 (14.3)	0	0.88
Prothrombin (G20210A)	30	29 (96.7)	1 (3.3)	0	8	7 (87.5)	1 (12.5)	0	0.302
Factor XIII (V34L)	7	6 (85.7)	1 (14.3)	0	4	4 (100)	0	0	0.428
β-Fibrinojen (-455G > A)	18	12 (66.7)	6 (33.3)	0	6	5 (83.3)	1 (16.7)	0	0.437
MTHFR (C677T)	15	9 (60)	3 (20)	3 (20)	7	4 (57.1)	2 (28.6)	1 (14.3)	0.884
MTHFR (A1298C)	48	10 (20.8)	37 (77.1)	1 (2.1)	39	2 (5.1)	37 (94.9)	0	0.008
APOB (R3500Q)	13	13 (100)	0	0	4	4 (100)	0	0	Not estimated
PAI-1 (4G/5G)	19	5G/5G	5G/4G	4G/4G	7	5G/5G	5G/4G	4G/4G
PAI-1 (4G/5G)	19	8 (42.1)	8 (42.1)	3 (15.8)	7	4 (57.1)	1 (14.3)	2 (28.6)	0.401
HPA-1 (1a/1b)	15	1a/1a	1a/1b	1b/1b	5	1a/1a	1a/1b	1b/1b
HPA-1 (1a/1b)	15	10 (66.7)	5 (33.3)	0	5	5 (100)	0	0	0.136
ACE (intron 16 I/D)	43	DEL	DEL/INS	INS	25	DEL	DEL/INS	INS
ACE (intron 16 I/D)	43	2 (4.7)	30 (69.8)	11 (25.6)	25	2 (8)	17 (68)	6 (24)	0.85
APOE (E2, E3. E4)	36	E2/E3	E3/E3	E3/E4	11	E2/E3	E3/E3	E3/E4
APOE (E2, E3. E4)	36	4 (4.7)	30 (69.8)	2 (5.6)	11	0	10 (90.9)	1 (9.1)	0.486

The statistically significant results are written in bold. ACE: Angiotensin converting enzyme; APOB: Apolipoprotein B; APOE: Apolipoprotein E; HPA-1: Human platelet antigen 1; MTHFR: Methylene tetrahydrofolate reductase; PAI-1: Plasminogen activator inhibitor-1; *Evaluated by Pearson’s Chi squared test.