Table 2: The genotypic frequencies of twelve mutations in ten cardiovascular disease genes in coronary artery patients and healthy control groups.

 

Coronary artery patients

Healthy controls

 

Gene mutations

n

Homozygote Wild type

Heterozygote

Homozygote

N

Homozygote Wild type

Heterozygote

Homozygote Mutant

p value*

(Total)

n (%)

n (%)

Mutant

(Total)

n (%)

n (%)

n (%)

 

 

 

n (%)

 

 

 

 

Factor V Leiden

27

26 (96.3)

1 (3.7)

0

8

8 (100)

0

0

0.581

Factor V (H1299R)

24

20 (83.3)

4 (16.7)

0

7

6 (85.7)

1 (14.3)

0

0.88

Prothrombin (G20210A)

30

29 (96.7)

1 (3.3)

0

8

7 (87.5)

1 (12.5)

0

0.302

Factor XIII (V34L)

7

6 (85.7)

1 (14.3)

0

4

4 (100)

0

0

0.428

β-Fibrinojen (-455G > A)

18

12 (66.7)

6 (33.3)

0

6

5 (83.3)

1 (16.7)

0

0.437

MTHFR (C677T)

15

9 (60)

3 (20)

3 (20)

7

4 (57.1)

2 (28.6)

1 (14.3)

0.884

MTHFR (A1298C)

48

10 (20.8)

37 (77.1)

1 (2.1)

39

2 (5.1)

37 (94.9)

0

0.008

APOB (R3500Q)

13

13 (100)

0

0

4

4 (100)

0

0

Not estimated

PAI-1 (4G/5G)

19

5G/5G

5G/4G

4G/4G

7

5G/5G

5G/4G

4G/4G

 

8 (42.1)

8 (42.1)

3 (15.8)

4 (57.1)

1 (14.3)

2 (28.6)

0.401

HPA-1 (1a/1b)

15

1a/1a

1a/1b

1b/1b

5

1a/1a

1a/1b

1b/1b

 

10 (66.7)

5 (33.3)

0

5 (100)

0

0

0.136

ACE (intron 16 I/D)

43

DEL

DEL/INS

INS

25

DEL

DEL/INS

INS

 

2 (4.7)

30 (69.8)

11 (25.6)

2 (8)

17 (68)

6 (24)

0.85

APOE (E2, E3. E4)

36

E2/E3

E3/E3

E3/E4

11

E2/E3

E3/E3

E3/E4

 

4 (4.7)

30 (69.8)

2 (5.6)

0

10 (90.9)

1 (9.1)

0.486

The statistically significant results are written in bold. ACE: Angiotensin converting enzyme; APOB: Apolipoprotein B; APOE: Apolipoprotein E; HPA-1: Human platelet antigen 1; MTHFR: Methylene tetrahydrofolate reductase; PAI-1: Plasminogen activator inhibitor-1; *Evaluated by Pearson’s Chi squared test.