Table 2: Dosages of the chemotherapy.

#

Underlying disease

Dosage melphalan

Dosage cytarabine

Intrathecal chemotherapy

Additional drugs

1

cALL

1 × 40 mg/m2

4 × 1 g/m2

Cytarabine 30 mg

Anti CD19 antibody 20 mg/m2

2

pro-B-ALL

1 × 60 mg/m2

4 × 1 g/m2

Cytarabine 20 mg, Prednisolone 6 mg

 

3

Mixed phenotype AL

2 × 60 mg/m²*

2 × 1 g/m2

 

 

4

AML M2

2 × 33 mg/m2

4 × 1 g/m2

 

 

5

ALL

1 × 20 mg/m²**

10 × 100 mg/m²**

Cytarabine 30 mg, Prednisolone 10 mg

 

6

pro-B-ALL

1 × 40 mg/m2

4 × 1 g/m2

Cytarabine 20 mg, Prednisolone 6 mg

 

7

T-lymphoblastic lymphoma

1 × 40 mg/m2

2 × 1 g/m2

 

Daratumomab 16 mg/kg

8

AML M2 Auer

1 × 40 mg/m2

5 × 100 mg/m2**

 

Venetoclax 100 mg and 200 mg

*High dosage because of a very aggressive form of AML as underlying disease; **Low dosage because of high cumulative toxicity prior to melphalan/cytarabine. ALL: Acute Lymphoblastic Leukemia; AML: Acute Myeloid Leukemia