Effects of intravermis cerebellar microinjections of VUF-8430 in mice exposed (OF1) and re-exposed (OF2) to the open field test.

Table 1: Effects of intravermis cerebellar microinjections of VUF-8430 in mice exposed (OF1) and re-exposed (OF2) to the open field test.

Behaviour	OF1	OF2
Behaviour	Pool	SAL	VUF 0.15 nmol	VUF 0.49 nmol	VUF 1.48 nmol
Crossed quadrants	185.83 ± 12.67	190.20 ± 30.41	150.80 ± 19.44	188.18 ± 31.24	163.27 ± 31.40
Number of readings	30.33 ± 2.92	39.90 ± 7.94	29.40 ± 6.65	26.55 ± 5.44	25.82 ± 5.38
Time in the central area	31.74 ± 3.41	27.20 ± 6.91	34.20 ± 8.20	22.48 ± 5.00	18.96 ± 3.12
Time of freezing	1.56 ± 0.77	4.60 ± 2.39	1.48 ± 0.82	5.47 ± 2.71	12.50 ± 3.71^*

The data are presented as the mean values (± SEM). The number of crossed quadrants, number of rearings, time spent in the central area and time of freezing were measured at OF1 and OF2. One- way ANOVA did not show significant differences among groups at OF1, which allowed the use of OF1 as a pool. ^*: Significant difference between test days (OF1 and OF2) p < 0.05.