Table
4: Simulation
results when true hazard ratio = 0.8.
|
Control median |
Sample size |
Percent censored |
Bias |
ASE |
ESD |
Proportion of HR |
||
|
< 0.5 |
< 0.4 |
< 0.3 |
||||||
|
6 |
800 |
9.1 |
0.0000 |
0.0745 |
0.0742 |
0.0000 |
0.0000 |
0.0000 |
|
600 |
9.1 |
-0.0010 |
0.0860 |
0.0856 |
0.0000 |
0.0000 |
0.0000 |
|
|
400 |
9.1 |
-0.0014 |
0.1055 |
0.1070 |
0.0000 |
0.0000 |
0.0000 |
|
|
200 |
9.1 |
0.0006 |
0.1495 |
0.1508 |
0.0010 |
0.0000 |
0.0000 |
|
|
100 |
9.2 |
-0.0012 |
0.2124 |
0.2104 |
0.0152 |
0.0014 |
0.0000 |
|
|
50 |
9.3 |
-0.0035 |
0.3037 |
0.3175 |
0.0740 |
0.0156 |
0.0018 |
|
|
12 |
800 |
29.5 |
-0.0014 |
0.0845 |
0.0850 |
0.0000 |
0.0000 |
0.0000 |
|
600 |
29.5 |
-0.0029 |
0.0976 |
0.0986 |
0.0000 |
0.0000 |
0.0000 |
|
|
400 |
29.5 |
0.0000 |
0.1197 |
0.1176 |
0.0000 |
0.0000 |
0.0000 |
|
|
200 |
29.5 |
0.0042 |
0.1695 |
0.1693 |
0.0036 |
0.0000 |
0.0000 |
|
|
100 |
29.6 |
-0.0008 |
0.2409 |
0.2389 |
0.0280 |
0.0028 |
0.0002 |
|
|
50 |
29.7 |
-0.0042 |
0.3436 |
0.3462 |
0.0878 |
0.0270 |
0.0048 |
|
|
24 |
800 |
53.9 |
-0.0004 |
0.1047 |
0.1045 |
0.0000 |
0.0000 |
0.0000 |
|
600 |
53.9 |
0.0007 |
0.1210 |
0.1207 |
0.0000 |
0.0000 |
0.0000 |
|
|
400 |
54.0 |
-0.0035 |
0.1485 |
0.1500 |
0.0004 |
0.0000 |
0.0000 |
|
|
200 |
54.1 |
-0.0044 |
0.2109 |
0.2123 |
0.0164 |
0.0006 |
0.0000 |
|
|
100 |
54.1 |
0.0031 |
0.3002 |
0.3025 |
0.0576 |
0.0128 |
0.0006 |
|
|
50 |
54.2 |
-0.0037 |
0.4311 |
0.4364 |
0.1382 |
0.0592 |
0.0152 |
|
Median HR rounded
to two decimal places was 0.80 in all cases except for one case when it was
0.81 (Control median = 24, Sample size = 50).