Table 4: Simulation results when true hazard ratio = 0.8.

Control median

Sample size

Percent censored

Bias

ASE

ESD

Proportion of HR

< 0.5

< 0.4

< 0.3

6

800

9.1

0.0000

0.0745

0.0742

0.0000

0.0000

0.0000

600

9.1

-0.0010

0.0860

0.0856

0.0000

0.0000

0.0000

400

9.1

-0.0014

0.1055

0.1070

0.0000

0.0000

0.0000

200

9.1

0.0006

0.1495

0.1508

0.0010

0.0000

0.0000

100

9.2

-0.0012

0.2124

0.2104

0.0152

0.0014

0.0000

50

9.3

-0.0035

0.3037

0.3175

0.0740

0.0156

0.0018

12

800

29.5

-0.0014

0.0845

0.0850

0.0000

0.0000

0.0000

600

29.5

-0.0029

0.0976

0.0986

0.0000

0.0000

0.0000

400

29.5

0.0000

0.1197

0.1176

0.0000

0.0000

0.0000

200

29.5

0.0042

0.1695

0.1693

0.0036

0.0000

0.0000

100

29.6

-0.0008

0.2409

0.2389

0.0280

0.0028

0.0002

50

29.7

-0.0042

0.3436

0.3462

0.0878

0.0270

0.0048

24

800

53.9

-0.0004

0.1047

0.1045

0.0000

0.0000

0.0000

600

53.9

0.0007

0.1210

0.1207

0.0000

0.0000

0.0000

400

54.0

-0.0035

0.1485

0.1500

0.0004

0.0000

0.0000

200

54.1

-0.0044

0.2109

0.2123

0.0164

0.0006

0.0000

100

54.1

0.0031

0.3002

0.3025

0.0576

0.0128

0.0006

50

54.2

-0.0037

0.4311

0.4364

0.1382

0.0592

0.0152

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Median HR rounded to two decimal places was 0.80 in all cases except for one case when it was 0.81 (Control median = 24, Sample size = 50).