Table
5: Simulation
results when true hazard ratio = 0.7.
|
Control median |
Sample size |
Percent censored |
Bias |
ASE |
ESD |
Proportion of HR |
||
|
< 0.5 |
< 0.4 |
< 0.3 |
||||||
|
6 |
800 |
10.9 |
0.0007 |
0.0755 |
0.0746 |
0.0000 |
0.0000 |
0.0000 |
|
600 |
10.9 |
-0.0010 |
0.0872 |
0.0880 |
0.0002 |
0.0000 |
0.0000 |
|
|
400 |
10.9 |
-0.0006 |
0.1069 |
0.1050 |
0.0006 |
0.0000 |
0.0000 |
|
|
200 |
10.9 |
0.0008 |
0.1516 |
0.1515 |
0.0152 |
0.0000 |
0.0000 |
|
|
100 |
11.0 |
-0.0057 |
0.2155 |
0.2189 |
0.0656 |
0.0054 |
0.0002 |
|
|
50 |
11.0 |
-0.0143 |
0.3078 |
0.3170 |
0.1514 |
0.0422 |
0.0062 |
|
|
12 |
800 |
31.9 |
0.0004 |
0.0863 |
0.0880 |
0.0000 |
0.0000 |
0.0000 |
|
600 |
31.9 |
-0.0003 |
0.0997 |
0.1004 |
0.0002 |
0.0000 |
0.0000 |
|
|
400 |
32.0 |
0.0015 |
0.1222 |
0.1200 |
0.0022 |
0.0000 |
0.0000 |
|
|
200 |
31.9 |
-0.0004 |
0.1732 |
0.1722 |
0.0244 |
0.0012 |
0.0000 |
|
|
100 |
32.0 |
-0.0053 |
0.2461 |
0.2436 |
0.0874 |
0.0136 |
0.0006 |
|
|
50 |
32.2 |
-0.0100 |
0.3518 |
0.3592 |
0.1784 |
0.0644 |
0.0088 |
|
|
24 |
800 |
56.0 |
-0.0018 |
0.1078 |
0.1068 |
0.0018 |
0.0000 |
0.0000 |
|
600 |
56.0 |
-0.0035 |
0.1245 |
0.1249 |
0.0042 |
0.0000 |
0.0000 |
|
|
400 |
56.1 |
-0.0023 |
0.1528 |
0.1539 |
0.0166 |
0.0002 |
0.0000 |
|
|
200 |
56.0 |
-0.0016 |
0.2166 |
0.2151 |
0.0622 |
0.0058 |
0.0000 |
|
|
100 |
56.2 |
-0.0105 |
0.3095 |
0.3084 |
0.1436 |
0.0408 |
0.0056 |
|
|
50 |
56.4 |
-0.0138 |
0.4466 |
0.4621 |
0.2320 |
0.1110 |
0.0402 |
|
Median
HR rounded to two decimal places was 0.70 in all cases except for two cases
when it was 0.69 (Control median = 6, Sample size = 100 and Control median =
24, Sample size = 0).