Table
6: Select
simulation results with unequal allocation.
|
True HR |
SS |
Ctrl med |
Alloc. ratio |
Percent censored |
Bias |
ASE |
ESD |
Med HR |
Proportion of
HR |
||
|
< 0.5 |
< 0.4 |
< 0.3 |
|||||||||
|
1 |
100 |
12 |
1:1 |
25.7 |
0.0028 |
0.2338 |
0.2360 |
1.00 |
0.0022 |
0.0002 |
0.0000 |
|
|
2:1 |
25.7 |
0.0007 |
0.2494 |
0.2495 |
1.00 |
0.0020 |
0.0000 |
0.0000 |
||
|
24 |
1:1 |
50.4 |
-0.0035 |
0.2875 |
0.2902 |
1.00 |
0.0112 |
0.0020 |
0.0000 |
||
|
|
2:1 |
49.4 |
0.0056 |
0.3070 |
0.3092 |
1.00 |
0.0116 |
0.0008 |
0.0000 |
||
|
50 |
12 |
1:1 |
26.0 |
-0.0099 |
0.3341 |
0.3357 |
0.99 |
0.0198 |
0.0036 |
0.0002 |
|
|
|
2:1 |
25.7 |
0.0027 |
0.3506 |
0.3582 |
1.00 |
0.0246 |
0.0056 |
0.0008 |
||
|
24 |
1:1 |
50.8 |
-0.0062 |
0.4136 |
0.4207 |
1.00 |
0.0520 |
0.0162 |
0.0030 |
||
|
|
2:1 |
50.6 |
0.0218 |
0.4354 |
0.4420 |
1.01 |
0.0482 |
0.0146 |
0.0018 |
||
|
0.7 |
100 |
12 |
1:1 |
32.0 |
-0.0053 |
0.2461 |
0.2436 |
0.70 |
0.0874 |
0.0136 |
0.0006 |
|
|
2:1 |
34.1 |
-0.0052 |
0.2583 |
0.2627 |
0.70 |
0.0976 |
0.0174 |
0.0012 |
||
|
24 |
1:1 |
56.2 |
-0.0105 |
0.3095 |
0.3084 |
0.69 |
0.1436 |
0.0408 |
0.0056 |
||
|
|
2:1 |
58.1 |
0.0042 |
0.3230 |
0.3220 |
0.70 |
0.1458 |
0.0366 |
0.0036 |
||
|
50 |
12 |
1:1 |
32.2 |
-0.0100 |
0.3518 |
0.3592 |
0.70 |
0.1784 |
0.0644 |
0.0088 |
|
|
|
2:1 |
34.5 |
-0.0109 |
0.3638 |
0.3613 |
0.69 |
0.1834 |
0.0622 |
0.0108 |
||
|
24 |
1:1 |
56.4 |
-0.0138 |
0.4466 |
0.4621 |
0.70 |
0.2320 |
0.1110 |
0.0402 |
||
|
|
2:1 |
58.0 |
0.0037 |
0.4569 |
0.4640 |
0.70 |
0.2268 |
0.1084 |
0.0320 |
||
For allocation ratio 2:1, sample sizes
considered were n = 99 and n = 51 respectively.