Table 2: Main characteristics of the five reported cases

Smith et al. [8] Pollock et al. [9] First lumbar puncture Pollock et al. [9] Second lumbar puncture Saffran et al. [10] Alsolaiman et al. [11] Gooch et Al. [12]
CSF
WBC count (/mm3)
Protein level (g/L)
Glucose level
Confirmed HSV 1 encephalitis

259
0.86
Normal
+
(PCR)

normal
0.93
Normal
-
(Immunofixation)

280
2.7
Normal
+
(necropsy)

68
0,51
Normal
-

20
0.41
Normal
NA (MRI consistent with HSV)

70
0.42
Normal
-
(PCR)
Antiviral therapy by acyclovir Yes
(delayed of about 2 days)
Yes
(delayed of 12 days)
Yes
(delayed about 3 days
Yes
(delayed about 6 days)
Yes
(delayed about 2 or 3 days)
Temporary cardiac pacing + - + + -
Permanent cardiac pacing - + - - +
Neurologic sequelae - memory impairment - langage skills NA - - -
Recurrence of sinus node dysfunction - NA - - -
Death - + - - -
Encephalitis diagnosis according to IEC Confirmed Confirmed Probable Probable Unlikely


Abbreviations: CSF: Cerebrospinal Fluid, HSV: Herpes Simplex Encephalitis, IEC: International Encephalitis Consortium, MRI: Magnetic Resonance Imaging ND: Not Done, PCR: Polymerase Chain Reaction, WBC: White Blood Cell