Table 1: Baseline demographic characteristics of the overall population.
| Overall (n = 71) | MitraClip Group (n = 40) | No-MitraClip Group (n = 3 1) | p value | |
| Age (years) | 70 (64-76) | 71.5 (67-77) | 69 (59-72) | 0.042 |
| Men, n (%) | 49 (69%) | 32 (80%) | 17 (54.8%) | 0.023 |
| BMI (Kg/m2) | 26 ± 3.6 | 25.6 ± 3.9 | 26.5 ± 3.1 | 0.310 |
| Idiopathic CMD, n (%) | 47 (66.2%) | 22 (55%) | 25 (80.6%) | 0.023 |
| Hypertension, n (%) | 52 (73.2%) | 31 (77.5%) | 21 (67.7%) | 0.357 |
| Diabetes, n (%) | 16 (22.5%) | 12 (30%) | 4 (12.9%) | 0.151 |
| Dyslipidemia, n (%) | 38 (53.5%) | 20 (50%) | 18 (58.1%) | 0.499 |
| Prior MI, n (%) | 15 (21.1%) | 11 (27.5%) | 4 (12.9%) | 0.156 |
| Valve Surgery, n (%) | 7 (9.9%) | 4 (10%) | 3 (9.7%) | 1.000 |
| Prior Stroke, n (%) | 6 (8.5%) | 3 (7.5%) | 3 (9.7%) | 1.000 |
| AF, n (%) | 36 (50.7%) | 19 (47.5%) | 17 (54.8%) | 0.540 |
| COPD, n (%) | 15 (21.1%) | 8 (20%) | 7 (22.6%) | 0.792 |
| Solid Tumours, n (%) | 7 (9.9%) | 3 (7.5%) | 4 (12.9%) | 0.691 |
| CKD, n (%) | 36 (50.7%) | 26 (65%) | 10 (32.3%) | 0.006 |
| Dialysis, n (%) | 4 (5.6%) | 2 (5%) | 2 (6.5%) | 1.000 |
| GFR (mL/min) | 49 (37-68) | 42 (34-58) | 56 (39-84) | 0.009 |
| EuroSCORE II (%) | 5.1 (3.1-8.9) | 6 (3.5-10.3) | 3.6 (2.2-6.8) | 0.009 |
| STS mortality (%) | 2.2 (1.2-5.0) | 3.7 (1.7-6.4) | 1.3 (0.75-2.4) | 0.000 |
| STS morbidity (%) | 22 (16.1-31.5) | 27.3 (19.7-42.1) | 16.7 (12.1-23.8) | 0.000 |
| NYHA Class | 3 (2-3) | 3 (3-3) | 2 (2-3) | 0.000 |
| NYHA III-IV, n (%) | 40 (56.3%) | 31 (77.5%) | 9 (22.5%) | 0.000 |
| Responders CRT, n (%) | 9 (12.7%) | 6 (15%) | 3 (9.7%) | 0.504 |
| Baseline Echo Variables | ||||
| LVEF (%) | 28 (24-35) | 25 (21-32) | 30 (25-35) | 0.016 |
| EDV-LV (ml) | 190 (150-241) | 209 (160-266) | 170 (113-215) | 0.023 |
| ESV-LV (ml) | 136 (94-184) | 150 (95-210) | 110 (80-150) | 0.013 |
| sPAP (mmHg) | 45 (40-60) | 50 (41-60) | 40 (36-60) | 0.089 |
| Mild-Moderate TR, n (%) | 59 (83.1%) | 33 (83.2%) | 26 (83.9%) | 0.878 |
Categorical variables are expressed as n (%). Continuous variables are expressed as mean ± SD and in case of skewed distribution as median and IQR.
Abbreviations: BMI: Body Mass Index; CMD: Dilated Cardiomyopathy; MI: Myocardial Infarction; AF: Atrial Fibrillation; COPD: Chronic Obstructive Pulmonary Disease; CKD: Chronic Kidney Disease; GFR: Glomerular Filtration Rate; STS: Society of Thoracic Surgery; NYHA: New York Heart Association Functional Classification; LVEF: Left Ventricular Ejection Fraction; EDV-LV: Left Ventricle End Diastolic Volume; ESV-LV: Left Ventricle End Systolic Volume; sPAPs: Systolic Pulmonary Artery Pressure; TR: Tricuspid Regurgitation.