Table 4: Comparison between hypertensive patients with HFpEF and HFrEF.

Variables

HFpEF

n = 76

HFrEF

n = 26

p value

Mean ± SD age (years)

61 ± 11

57 ± 14

0.113

Age ≥ 55 years, n (%)

57 (75)

14 (53.8)

0.023

Women, n (%)

49 (64.5)

15 (58)

0.64

Inpatients, n (%)

14 (18.4)

11 (42.3)

0.02

Diabetes, n (%)

10 (13.2)

6 (23.1)

0.348

Symptoms, n (%)

 

 

 

Shortness of breath

68 (89.5)

25 (96.2)

0.442

Palpitation

48 (63.2)

16 (61.5)

0.912

Orthopnea

51 (67.1)

18 (69.2)

0.987

PND

17 (22.4)

15 (57.7)

0.001

Lower limb swelling

48 (63.2)

15 (57.7)

0.367

Right upper quadrant pain

3 (4)

3 (11.4)

0.334

Nocturnal cough

42 (55.3)

20 (76.9)

0.051

Physical findings

 

 

 

Mean ± SD Pulse rate (beats/min)

79 ± 18

86 ± 17

0.063

Mean ± SD SBP (mmHg)

157 ± 23

142 ± 28

0.011

Mean ± SD DBP (mmHg)

92 ± 23

89 ± 17

0.258

Mean ± SD BMI (kg/m2)

29 ± 6.4

26.2 ± 6.6

0.058

Obesity, n (%)

33 (43.4)

6 (23.1)

0.001

Signs, n (%)

 

 

 

 Raised JVP

6 (7.9)

3 (11.5)

0.690

 Shifted Apex beat

13 (17.1)

12 (46.2)

0.005

Gallop rhythm

11 (14.5)

20 (76.9)

0.000

Basal crepitation

3 (3.9)

7 (26.9)

0.002

Lower limb edema

30 (39.5)

13 (50)

0.367

Laboratory findings

 

 

 

 Mean ± SD Hemoglobin (g/dl)

12.4 ± 1.6

11.6 ± 2

0.001

 Mean ± SD Creatinine (µmol/l)

121.5 ± 87

130.7 ± 117

0.11

 Mean ± SD BUN (mmol/l)

12 ± 12.7

12.2 ± 8.8

0.15

 Mean ± SD eGFR (ml/min/1.73 m2)

68.6 ± 24

70.6 ± 30

0.204

 Renal dysfunction, n (%)

22 (28.9)

10 (38.5)

0.463

Echocardiographic findings

 

 

 

 Interventricular septum in diastole (cm)

1.35 ± 0.2

1.1 ± 0.3

0.001

 LV internal diameter in diastole (cm)

4.6 ± 0.6

5.6 ± 0.8

0.000

 Left atrial volume index (ml/m2)

32.5 ± 12

43.4 ± 16

0.001

 Proportion with LVH, n (%)s

57 (75)

22 (84.6)

0.419

 Proportion with enlarged LA n (%)

32 (42.1)

16 (61.5)

0.112

Mean ± SD E/E'

15.8 ± 5

20.9 ± 11

0.002

BMI: Body Mass Index; PND: Paroxysmal Nocturnal Dyspnea; JVP: Jugular Venous Pressure; n: Number; SD: Standard Deviation, HFpEF: Heart Failure with Preserved Ejection Fraction; HFrEF: Heart Failure with Reduced Ejection Fraction