Table 4: General characteristics of patients depending on the concentrations of MR-proADM stratified into quartiles. Quantitative variables.

Variable

n

I Quartil
(n = 56)
< 0.5 nmol/L

II Quartil
(n = 44)
0.51-0.57 nmol/L

III Quartil
(n = 44)
0.571-0.718 nmol/L

IV Quartil
(n = 47)
> 0.718 nmol/L

P value*

Personal characteristics

Age (median)

191

79 (20)

80 (12)

77 (15)

77 (11)

ns

BMI (mean)

173

30.74 ± 9.01

31.28 ± 7.14

29.85 ± 5.73

30.51 ± 6.66

ns

Vital status variables

Glasgow (median)

184

15 (3)

15 (0)

15 (1)

15 (2t)

ns

MAP (median)

181

94 (24)

92 (22)

92 (19)

91 (27)

ns

H.R. (media)

181

91 ± 18

90 ± 25

89 ± 22

91 ± 23

ns

Temp. (median)

181

36.4 (0.8)

36.6 (0.9)

36.5 (1)

36.4 (0.7)

ns

Laboratory variables

pH (mean)

190

7.29 ± 0.1

7.28 ± 0.09

7.28 ± 0.1

7.27 ± 0.11

ns

PaCO2 (median)

191

66.07 (40.03)

57.36 (26.4)

54.36 (23.56)

62.82 (18.5)

ns

HCO3- (mean)

191

27.7 ± 6.4

24.5 ± 4.7

23.9 ± 5.6

25.1 ± 6.1

ns

PaO2/FiO2 (mean)

77

210 ± 102

208 ± 97

211 ± 118

231 ± 172

ns

Lact. (median)

182

1.5 (1.5)

1.8 (1.7)

1.8 (1.7)

1.9 (2.1)

ns

Hb. (mean)

191

12.4 ± 2.03

12.4 ± 2.02

12.9 ± 2.4

12.5 ± 2.2

ns

Leuk. (mean)

191

10.8 ± 4.5

11.7 ± 4.3

11.8 ± 4.4

12.7 ± 7.7

ns

Plat. (median)

191

251 (98)

226 (96)

232 (99)

262 (128)

ns

Urea (median)

191

49 (32)

56 (47)

58 (45)

61 (53)

ns

Creat. (median)

191

1.1 (0.6)

1.5 (0.6)

1.3 (0.8)

1.5 (0.8)

ns

Na+ (median)

191

139 (8)

139 (7)

138 (9)

140 (8)

ns

K+ (median)

177

4.6 (1.1)

4.6 (0.8)

4.6 (1.1)

4.5 (1.3)

ns

INR (median)

191

1.1 (0.5)

1.1 (0.5)

1.1 (0.4)

1.2 (1)

ns

 

Abbreviations and measurement units: BMI: body-mass index; MAP: mean arterial pressure (mmHg); H.R.: heart rate (beats per minute); Temp: temperature (degrees Celsius); PaCO2: arterial carbon dioxide tension (mmHg); HCO3-: bicarbonate in arterial blood (mmol/L); PaO2/FiO2: arterial oxygen tension/fraction of inspired oxygen; Lact.: lactic acid in arterial blood (mmol/L); Hb.: hemoglobin (gr/L); Leuk.: leukocytes (x1000); Plat.: platelets (x1000); Serum urea (mg/dL); Creat.: serum creatinine (mg/dL); Na+: sodium ion (mmol/L); K+: potassium ion (mmol/L); INR: international normalized ratio; MR-proADM: mid-regional proadrenomedullin (nmol/L); ns: not significant.

 

Note: The means are expressed with standard deviation and they make reference to variables with normal distribution while the medians are expressed followed (in parentheses) of the interquartile range and refer to non-parametric variables.

*Comparisons between groups were performed by the ANOVA test for normally distributed variables and Kruskal-Wallis for non-parametric.