Table 1: Comparison between normotensive and hypotensive patients according to demographic characteristics, propofol infusion, diagnosis on admission and past medical history.
| Normotensive (n = 47) | Hypotensive (n = 53) | Unadjusted RR (95% CI) | P value | |
| Age (years) | 37.3 (14.6) | 52.0 (17.1) | 1.02[1.01;1.04] | < 0.001 |
| Female, n (%) | 15 (31.9) | 30 (56.6) | 1.59[1.09;2.31] | 0.035 |
| Weight (kg) | 83.6 (11.5) | 78.9 (12.4) | 0.98[0.96;1.01] | 0.049 |
| Indication of Propofol infusion | ||||
| Sedation on MV | 35 (74.4) | 37 (69.8) | 0.92[0.5;1.70] | 0.66 |
| Convulsions | 15 (31.9) | 13 (24.5) | ||
| Rate of propofol infusion (µg/kg/min), median (25th - 75th) | 26.0 (5.0) | 25.0 (9.0) | 0[0;2.e+12] | 0.6 |
| Heart rate (beat/min) | 90 (13.2) | 90 (10) | 0.96[0.76;1.2] | 0.12Hypoxic index |
| Hypoxic index | 231.27 (77.63) | 170.09 (53.02) | 0.99[0.99;1] | < 0.001 |
| Serum Creatinine (mg/dl) | 0.979 (0.235) | 2.41 (1.97) | 1.19[1.06;1.33] | < 0.001 |
| Bicarbonate (mlEq/L) | 21.5 (4.7) | 17.35 (3.58) | 0.9[0.84;0.96] | < 0.001 |
| Diagnosis on admission, n (%) | ||||
| Traumatic brain injury | 19 (40.4) | 1 (1.8) | 0.08[0.01;0.056] | < 0.001 |
| Intracranial Hemorrhage | 16 (34.0) | 11 (20.7) | 0.66[0.33;1.32] | 0.13 |
| Status epileptics | 12 (25.5) | 11 (20.7) | 0.87[0.44;1.74] | 0.55 |
| Heart failure | 1 (2.1) | 4 (7.5) | 1.55[0.56;4.3] | 0.35 |
| Respiratory failure | 12 (25.5) | 21 (39.6) | 1.35[0.77;2.35] | 0.15 |
| Severe sepsis | 0 | 26 (49.05) | 2.68[1.56;4.59] | < 0.001 |
| Burn | 3 (6.3) | 4 (7.5) | 1.28[0.46;3.54] | 1.00 |
| Snake bite | 0 | 1 (1.8) | 1.9[0.26;13.77] | 1.00 |
| APACHE II score | 7.7 (3.4) | 14.7 (5.6) | 1.08[1.04;1.13] | < 0.001 |
| MAP at initiation of propofol infusion | 104 (11) | 87 (12) | 0.96[0.94;0.98] | < 0.001 |
| RRT need n (%) | 0 | 14 (26.4) | 2.15[1.13;4.08] | 0.002 |
| Past medical history, n (%) | ||||
| Diabetes | 11 (23.4) | 26 (49.05) | 1.37[0.98 to 1.93] | 0.05 |
| Hypertension | 12 (25.5) | 20 (37.7) | 1.29[0.74;2.24] | 0.21 |
| Chronic Congestive heart failure | 1 (2.1) | 5 (9.4) | 1.63[0.65;4.10] | 0.21 |
| Atrial fibrillation | 0 | 6 (11.3) | 2.0[1.63 to 2.44] | 0.029 |
| Acute kidney injury | 0 | 23 (43.3) | 2.57[1.48;4.45] | < 0.001 |
| End stage renal disease | 0 | 7 (13.2) | 2.02[1.64 to 2.48] | 0.014 |
| Liver cirrhosis | 2 (4.2) | 9 (16.9) | 1.65[1.16 to 2.34] | 0.042 |
MAP: Mean Arterial Pressure; RRT: Renal Replacement Therapy.