Table 2: Genotype and allele frequencies of PON1 gene polymorphisms in acute stroke patients and healthy controls.
|
Polymorphisms |
Acute Stroke patients n = 107 (%) |
Healthy controls n = 99 (%) |
p |
OR (CI 95%) |
|
Q192R (rs662) |
HWE p = 0.026 |
HWE p = 0.846 |
||
|
Genotypes |
||||
|
QQ : QR : RR |
78 (72.9) : 23 (21.5) : 6 (5.6) |
58 (58.6) : 36 (36.4) : 5 (5.1) |
0.061 |
|
|
QQ : QR+RR |
78 (72.9) : 29 (27.1) |
58 (58.6) : 41 (41.4) |
0.030 |
0.53 (0.29-0.94) |
|
QQ+QR : RR |
101 (94.4) : 6 (5.6) |
94 (94.9) : 5 (5.1) |
0.859 |
1.12 (0.33-3.78) |
|
Alleles |
||||
|
Q : R |
179 (83.6) : 35 (16.4) |
152 (76.8) : 46 (23.2) |
0.079 |
0.65 (0.39-1.05) |
|
|
|
|
|
|
|
L55M (rs854560) |
HWE p = 0.556 |
HWE p = 0.296 |
||
|
Genotypes |
||||
|
LL : LM : MM |
44 (41.1) : 47 (43.9) : 16 (15.0) |
39 (39.4) : 50 (50.5) : 10 (10.1) |
0.479 |
|
|
LL : LM+MM |
44 (41.1) : 63 (58.9) |
39 (39.4) : 60 (60.6) |
0.801 |
0.93 (0.53-1.62) |
|
LL+LM : MM |
91 (85.0) : 16 (15.0) |
89 (89.9) : 10 (10.1) |
0.296 |
1.56 (0.67-3.63) |
|
Alleles |
||||
|
L : M |
135 (63.1) : 79 (36.9) |
128 (64.6) : 70 (35.4) |
0.742 |
1.07 (0.71-1.6) |
Data were analyzed by χ2. HWE: HardyWeinberg Equilibrium, PON1: Paraoxonase 1. The results that are statistically significant are shown in boldface.