Study

Region

L55M

Patients

Controls

p

OR (CI 95%)

Aydin et al., 2006 (24)

İstanbul

Genotypes

LL : LM : MM

12 (18.5) : 42 (64.6) : 11(16.9)

20 (23.8) : 29 (34.5) : 35 (41.7)

0.001

LL : LM+MM

12 (18.5) : 53 (81.5)

20 (23.8) : 64 (76.2)

0.430

0.725 (0.325-1.617)

LL+LM : MM

54 (83.1) : 11 (16.9)

49 (58.3) : 35 (41.7)

0.001

3.506 (1.607-7.650)

Alleles

L : M

66 (50.8) : 64 (49.2)

69 (41.1) : 99 (58.9)

0.095

1.480 (0.933-2.347)

Demirdöğen et al., 2009 (26)

Ankara

Genotypes

LL : LM : MM

83 (48.3) : 68 (39.5) : 21 (12.2)

44 (41.9) : 42 (40) : 19 (18.1)

0.343

LL : LM+MM

83 (48.3) : 89 (51.7)

44 (41.9) : 61 (58.1)

0.303

1.293 (0.792-2.110)

LL+LM : MM

151 (87.8) : 21 (12.2)

86 (81.9) : 19 (18.1)

0.176

1.589 (0.809-3.119)

Alleles

L : M

234 (68.0) : 110 (32.0)

130 (61.9) : 80 (38.1)

0.141

1.309 (0.914-1.875)

Present study

Tokat

Genotypes

LL : LM : MM

44 (41.1) : 47 (43.9) : 16 (15)

39 (39.4) : 50 (50.5) : 10 (10.1)

0.479

LL : LM+MM

44 (41.1) : 63 (58.9)

39 (39.4) : 60 (60.6)

0.801

1.074 (0.615-1.876)

LL+LM : MM

91 (85) : 16 (15)

89 (89.9) : 10 (10.1)

0.295

0.639 (0.275-1.484)

Alleles

L : M

135 (63.1) : 79 (36.9)

128 (64.6) : 70 (35.4)

0.742

0.935 (0.625-1.398)

Total studies

Genotypes

LL : LM : MM

139 (40.4) : 157 (45.6) : 48 (14)

103 (35.8) : 121 (42) : 64 (22.2)

0.025

LL : LM+MM

139 (40.4) : 205 (59.6)

103 (35.8) : 185 (64.2)

0.232

1.218 (0.882-1.682)

LL+LM : MM

296 (86.0) : 48 (14.0)

224 (77.8) : 64 (22.2)

0.007

1.762 (1.166-2.662)

Alleles

L : M

435 (63.2) : 253 (36.8)

327 (56.8) : 249 (43.2)

0.019

1.309 (1.044-1.642)