Table 5: Characteristics of the individual and total studies examined the association between acute ischemic stroke and PON1 gene L55M polymorphism in Turkish population.
Study |
Region |
L55M |
Patients |
Controls |
p |
OR (CI 95%) |
|
Aydin et al., 2006 (24) |
İstanbul |
Genotypes |
|||||
LL : LM : MM |
12 (18.5) : 42 (64.6) : 11(16.9) |
20 (23.8) : 29 (34.5) : 35 (41.7) |
0.001 |
||||
LL : LM+MM |
12 (18.5) : 53 (81.5) |
20 (23.8) : 64 (76.2) |
0.430 |
0.725 (0.325-1.617) |
|||
LL+LM : MM |
54 (83.1) : 11 (16.9) |
49 (58.3) : 35 (41.7) |
0.001 |
3.506 (1.607-7.650) |
|||
Alleles |
|||||||
L : M |
66 (50.8) : 64 (49.2) |
69 (41.1) : 99 (58.9) |
0.095 |
1.480 (0.933-2.347) |
|||
Demirdöğen et al., 2009 (26) |
Ankara |
Genotypes |
|||||
LL : LM : MM |
83 (48.3) : 68 (39.5) : 21 (12.2) |
44 (41.9) : 42 (40) : 19 (18.1) |
0.343 |
||||
LL : LM+MM |
83 (48.3) : 89 (51.7) |
44 (41.9) : 61 (58.1) |
0.303 |
1.293 (0.792-2.110) |
|||
LL+LM : MM |
151 (87.8) : 21 (12.2) |
86 (81.9) : 19 (18.1) |
0.176 |
1.589 (0.809-3.119) |
|||
Alleles |
|||||||
L : M |
234 (68.0) : 110 (32.0) |
130 (61.9) : 80 (38.1) |
0.141 |
1.309 (0.914-1.875) |
|||
Present study |
Tokat |
Genotypes |
|||||
LL : LM : MM |
44 (41.1) : 47 (43.9) : 16 (15) |
39 (39.4) : 50 (50.5) : 10 (10.1) |
0.479 |
||||
LL : LM+MM |
44 (41.1) : 63 (58.9) |
39 (39.4) : 60 (60.6) |
0.801 |
1.074 (0.615-1.876) |
|||
LL+LM : MM |
91 (85) : 16 (15) |
89 (89.9) : 10 (10.1) |
0.295 |
0.639 (0.275-1.484) |
|||
Alleles |
|||||||
L : M |
135 (63.1) : 79 (36.9) |
128 (64.6) : 70 (35.4) |
0.742 |
0.935 (0.625-1.398) |
|||
Total studies |
Genotypes |
||||||
LL : LM : MM |
139 (40.4) : 157 (45.6) : 48 (14) |
103 (35.8) : 121 (42) : 64 (22.2) |
0.025 |
||||
LL : LM+MM |
139 (40.4) : 205 (59.6) |
103 (35.8) : 185 (64.2) |
0.232 |
1.218 (0.882-1.682) |
|||
LL+LM : MM |
296 (86.0) : 48 (14.0) |
224 (77.8) : 64 (22.2) |
0.007 |
1.762 (1.166-2.662) |
|||
Alleles |
|||||||
L : M |
435 (63.2) : 253 (36.8) |
327 (56.8) : 249 (43.2) |
0.019 |
1.309 (1.044-1.642) |
PON1, Paraoxinase 1. The results that are statistically significant are shown in boldface.