Metabolites

Concentration of blood plasma metabolites/lipids (µM)

p-value

Patients with metastases PCa

n = 30  (Median, range)

Patients with PCa

N = 30 (Median, range)

Median

Min

Max

Median

Min

Max

Metabolomic profiling

Leucine

789.86

435.19

1698.70

943.67

536.98

1634.46

0.01

Isoleucine

281.68

145.35

450.05

324.11

116.91

706.91

0.02

Valine

349.90

188.97

579.11

386.75

120.42

743.73

0.02

Lactate

2684.39

1314.31

5691.74

4563.20

2260.23

10056.14

< 0.001

Alanine

547.47

309.56

1251.30

871.45

342.45

1386.03

< 0.001

Glutamate

457.16

284.29

865.03

639.48

409.21

1434.29

< 0.001

Pyruvate

68.68

32.72

110.17

130.68

51.16

404.27

< 0.001

Glutamine

869.93

197.22

1538.60

960.78

505.21

1666.93

0.14

Creatine

86.80

43.63

156.44

165.72

61.74

456.78

< 0.001

Phosphocreatine

60.49

7.58

193.95

50.25

15.35

485.79

0.09

Glycine

283.04

43.13

810.72

509.14

179.26

1007.50

< 0.001

Creatinine

147.91

43.22

312.72

273.21

113.47

759.86

< 0.001

Tyrosine

186.51

87.13

559.54

253.90

117.08

501.05

0.04

Histidine

136.36

75.61

255.18

161.34

48.60

290.29

0.01

Phenylalanine

195.62

82.29

592.26

292.76

126.81

790.58

0.004

Glucose

4689.70

3240.37

8333.94

5367.08

2683.88

17999.70

0.11

Lipidomic profiling

Betaine

203.85

87.07

1798.20

392.17

169.42

855.22

0.33

3-HOB

511.15

218.48

800.67

762.91

213.54

2158.81

< 0.001

Acetate

57.11

36.88

120.98

128.18

21.13

356.20

< 0.001

Acetoacetate

102.44

44.48

320.35

234.08

84.91

423.69

< 0.001

DMA

57.15

6.30

140.85

124.42

57.60

312.75

< 0.001

Malonate

61.05

0.67

1033.14

113.96

33.91

461.96

0.05

Choline

85.92

51.58

160.59

162.92

64.92

491.98

< 0.001

GPC

95.55

49.05

192.75

147.97

77.10

520.50

< 0.001