Inactive |
Low RPA(≤ 9.23 hrs/wk) |
High RPA (>9.23 hrs/wk) |
|||||||||
Genes |
Methylated/ Unmethylated |
OR |
95% CI |
|
Methylated/ Unmethylated |
OR |
95% CI |
|
Methylated/ Unmethylated |
OR |
95% CI |
APC |
69/67 |
1.00 |
reference
|
93/86 |
1.05 |
(0.67,
1.64) |
72/70 |
1.00 |
(0.62,
1.60) |
||
BRCA1 |
84/68 |
1.00 |
reference
|
117/71 |
1.34 |
(0.87,
2.07) |
85/66 |
1.04 |
(0.66,
1.64) |
||
CDH1 |
10/119 |
1.00 |
reference
|
14/164 |
1.00 |
(0.43,
2.33) |
4/131 |
0.37 |
(0.11,
1.19) |
||
CYCLIND2 |
31/98 |
1.00 |
reference
|
34/144 |
0.76 |
(0.44,
1.33) |
28/107 |
0.81 |
(0.45,
1.46) |
||
DAPK |
21/108 |
1.00 |
reference
|
24/154 |
0.82 |
(0.44,
1.56) |
26/109 |
1.21 |
(0.64,
2.29) |
||
ESR1 |
74/77 |
1.00 |
reference
|
85/101 |
0.87 |
(0.57,
1.34) |
62/89 |
0.73 |
(0.46,
1.15) |
||
GSTP1 |
38/91 |
1.00 |
reference
|
41/137 |
0.73 |
(0.43,
1.22) |
37/98 |
0.90 |
(0.53,
1.54) |
||
HIN |
76/53 |
1.00 |
reference
|
111/67 |
1.16 |
(0.73,
1.85) |
91/44 |
1.44 |
(0.87,
2.38) |
||
CDKN2A |
9/124 |
1.00 |
reference
|
6/166 |
0.48 |
(0.17,
1.39) |
5/133 |
0.52 |
(0.17,
1.59) |
||
PR |
19/133 |
1.00 |
reference
|
22/166 |
0.92 |
(0.48,
1.77) |
18/133 |
0.95 |
(0.48,
1.89) |
||
RARB |
43/86 |
1.00 |
reference
|
51/127 |
0.81 |
(0.50,
1.33) |
32/103 |
0.62 |
(0.36,
1.06) |
||
RASSF1A |
110/19 |
1.00 |
reference
|
154/24 |
1.13 |
(0.59,
2.18) |
111/24 |
0.79 |
(0.41,
1.53) |
||
TWIST |
22/107 |
1.00 |
reference
|
|
29/149 |
0.96 |
(0.52,
1.76) |
|
22/113 |
0.94 |
(0.49,
1.80) |
Table
2: Age-adjusted
odds ratios (ORs) and 95% confidence intervals (CIs) for the association
between postmenopausal recreational physical activity (RPA) and breast cancer,
defined by tumor gene-specific promoter methylation (comparing methylated vs.
unmethylated cases), in the Long Island Breast Cancer Study Project
(1996-1997).