Inactive

Low RPA(≤ 9.23 hrs/wk)

High RPA (>9.23 hrs/wk)

 Genes

Methylated/ Unmethylated

OR

95% CI

 

Methylated/ Unmethylated

OR

95% CI

 

Methylated/ Unmethylated

OR

95% CI

APC

69/67

1.00

reference

93/86

1.05

(0.67, 1.64)

72/70

1.00

(0.62, 1.60)

BRCA1

84/68

1.00

reference

117/71

1.34

(0.87, 2.07)

85/66

1.04

(0.66, 1.64)

CDH1

10/119

1.00

reference

14/164

1.00

(0.43, 2.33)

4/131

0.37

(0.11, 1.19)

CYCLIND2

31/98

1.00

reference

34/144

0.76

(0.44, 1.33)

28/107

0.81

(0.45, 1.46)

DAPK

21/108

1.00

reference

24/154

0.82

(0.44, 1.56)

26/109

1.21

(0.64, 2.29)

ESR1

74/77

1.00

reference

85/101

0.87

(0.57, 1.34)

62/89

0.73

(0.46, 1.15)

GSTP1

38/91

1.00

reference

41/137

0.73

(0.43, 1.22)

37/98

0.90

(0.53, 1.54)

HIN

76/53

1.00

reference

111/67

1.16

(0.73, 1.85)

91/44

1.44

(0.87, 2.38)

CDKN2A

9/124

1.00

reference

6/166

0.48

(0.17, 1.39)

5/133

0.52

(0.17, 1.59)

PR

19/133

1.00

reference

22/166

0.92

(0.48, 1.77)

18/133

0.95

(0.48, 1.89)

RARB

43/86

1.00

reference

51/127

0.81

(0.50, 1.33)

32/103

0.62

(0.36, 1.06)

RASSF1A

110/19

1.00

reference

154/24

1.13

(0.59, 2.18)

111/24

0.79

(0.41, 1.53)

TWIST

22/107

1.00

reference

 

29/149

0.96

(0.52, 1.76)

 

22/113

0.94

(0.49, 1.80)

 

Table 2: Age-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for the association between postmenopausal recreational physical activity (RPA) and breast cancer, defined by tumor gene-specific promoter methylation (comparing methylated vs. unmethylated cases), in the Long Island Breast Cancer Study Project (1996-1997).