Table 2: Results of meta-analysis for polymorphisms in USF1 and cancer susceptibility

Variables (rs2516839)

Case/Control

C vs. T

CC vs. TT

TC vs. TT

 

 

OR (95% CI)

Pa

I2 (%)

OR (95% CI)

Pa

I2

OR (95% CI)

Pa

I2

Total

582/1115

1.392(1.203-1.612)*

0.113

29.3

1.837(1.386-2.433)*

0.243

8.6

1.301(1.017-1.665)*

0.904

0.0

Source of control

 

 

 

 

 

 

 

 

 

 

HB

428/955

1.373(1.164-1.620)*

0.040

58.4

1.771(1.293-2.424)*

0.110

37.0

1.264(0.958-1.669)

0.936

0.0

Cancer Type

 

 

 

 

 

 

 

 

 

 

HCC

248/260

1.655(1.284-2.135)*

0.192

17.0

2.496(1.529-4.074)*

0.445

0.0

1.363(0.895-2.077)

0.717

0.0

 

Case/Control

CC+TC vs. TT

CC vs. TC+TT

 

 

 

 

 

OR (95% CI)

Pa

I2

OR (95% CI)

Pa

I2

 

 

 

Total

582/1115

1.486(1.185-1.863)*

0.594

0.0

1.548(1.219-1.965)*

0.155

21.4

 

 

 

Source of control

 

 

 

 

 

 

 

 

 

 

HB

428/955

1.450(1.125-1.869)

0.352

0.0

1.515(1.160-1.979)*

0.058

52.1

 

 

 

Cancer Type

 

 

 

 

 

 

 

 

 

 

HCC

248/260

1.727(1.184-2.519)*

0.749

0.0

2.037(1.324-3.134)*

0.228

9.7

 

 

 

Variables (rs2516838)

Case/Control

C vs. T

CC vs. TT

CT vs. TT

 

 

OR (95% CI)

Pa

I2 (%)

OR (95% CI)

Pa

I2 (%)

OR (95% CI)

Pa

I2 (%)

Total

428/954

1.004(0.564-1.788)

0.020

66.6

0.938(0.309-2.850)

0.070

48.3

1.096(0.565-2.127)

0.049

54.9

 

Case/Control

CC+CT vs. TT

CC vs. CT+TT

 

 

 

 

 

OR (95% CI)

Pa

I2 (%)

OR (95% CI)

Pa

I2 (%)

 

 

 

Total

428/954

1.082(0.523-2.237)

0.025

64.3

0.801(0.455-1.412)

0.168

22.4

 

 

 

Variables (rs2774276)

Case/Control

C vs. T

CC vs. TT

CT vs.TT

 

 

OR (95% CI)

Pa

I2 (%)

OR (95% CI)

Pa

I2

OR (95% CI)

Pa

I2

Total

428/954

0.914(0.804-1.040)

0.430

0.0

0.701(0.460-1.068)

0.560

0.0

0.966(0.851-1.096)

0.597

0.0

 

Case/Control

CC+CT vs. TT

CC vs. CT+TT

 

 

 

 

 

OR (95% CI)

Pa

I2

OR (95% CI)

Pa

I2

 

 

 

Total

428/954

0.947(0.846-1.062)

0.510

0.0

0.708(0.459-1.094)

0.600

0.0

 

 

 

Variables (rs3737787)

Case/Control

Cvs. T

CC vs. TT

TC vs. TT

 

 

OR (95% CI)

Pa

I2 (%)

OR (95% CI)

Pa

I2

OR (95% CI)

Pa

I2

Total

428/954

1.210(1.082-1.354)*

0.421

0.0

1.325(1.003-1.751)*

0.622

0.0

1.277(1.124-1.450)*

0.380

0.0

 

Case/Control

CC+CTvs. TT

CC vs. TC+TT

 

 

 

 

 

OR (95% CI)

Pa

I2 (%)

OR (95% CI)

Pa

I2

 

 

 

Total

428/954

1.227(1.105-1.362)*

0.362

0.0

1.143(0.852-1.534)

0.823

0.0

 

 

 

 

I2: 025, means no heterogeneity, 2550 means modest heterogeneity, 50 means high heterogeneity, PCR-RFLP: polymerase chain reaction-restriction fragment length polymorphism, Pa: P value of Q test for heterogeneity test, * means statistically significant (P0.05).