Table 1: Common Terminology Criteria for Adverse Events (CTCAE) v 4.03

	Grade
Adverse Event	1	2	3	4	5
Skin ulceration	Combined area of ulcers < 1 cm; nonblanchable erythema of intact skin with associated warmth or edema	Combined area of ulcers 1 - 2 cm; partial thickness skin loss involving skin or subcutaneous fat	Combined area of ulcers > 2 cm; full-thickness skin loss involving damage to or necrosis of subcutaneous tissue that may extend down to fascia	Any size ulcer with extensive destruction, tissue necrosis, or damage to muscle, bone, or supporting structures with or without full thickness skin loss	Death
Definition: A disorder characterized by circumscribed, inflammatory and necrotic erosive lesion on the skin.
	Grade
Adverse Event	1	2	3	4	5
Alopecia	Hair loss of < 50% of normal for that individual that is not obvious from a distance but only on close inspection; a different hair style may be required to cover the hair loss but it does not require a wig or hair piece to camouflage	Hair loss of >= 50% normal for that individual that is readily apparent to others; a wig or hair piece is necessary if the patient desires to completely camouflage the hair loss; associated with psychosocial impact	-	-	-
Definition: A disorder characterized by a decrease in density of hair compared to normal for a given individual at a given age and body location.