Table 1: List of cancer hallmark pathways with supporting literature. PMID – Pubmed ID of the article used for pathway reconstruction. Cancer hallmark processes are borrowed from [13].

Cancer Hallmark	Pathway Name	Number of entities	Number of relations	Publication PMIDs
Sustaining proliferation	EGFR activation by apoptotic clearance	69	91	16000554, 12069816, 15273989
Sustaining proliferation	Cell cycle	144	225	Available in Pathway Studio
Sustaining proliferation	Bombesin trans-activation of EGFR	51	75	12069816, 16377102
Sustaining proliferation	F2 -> AP-1/CREB/ELK-SRF/SP1 Expression Targets	128	200	Available in Pathway Studio
Sustaining proliferation	DREAM complex->quiescence	27	36	23842645
Resisting cell death	Extrinsic and Intrinsic Apoptosis pathways	100	166	Available in Pathway Studio
Resisting cell death	Hypoxia->ROS->Apoptosis	45	62	11266442,
Resisting cell death	oxLDL->apoptosis	20	18
Resisting cell death	F2 -> STAT1/NF-kB Expression Targets	94	102	Available in Pathway Studio
Angiogenesis	Hypoxia->ROS->HIF->Angiogenesis	49	88
Angiogenesis	Blood vessel maturation and stability	54	90
Angiogenesis	VEGFR->endothelial proliferation	74	151
Angiogenesis	oxLDL->angiogenesis	57	66
Angiogenesis	TNC->angiogenesis	47	81
Angiogenesis	F2->Angiogenesis	35	51	15598469
Invasion & Metastasis	ICAM1 -> AP-1/CREB/ELK-SRF signaling	29	51	Available in Pathway Studio
Invasion & Metastasis	Wnt ->EMT	52	72
Invasion & Metastasis	Hypoxia->EMT	43	76
Invasion & Metastasis	FGFs stabilize RUNX2	47	67	12110689, 12403780
Invasion & Metastasis	TGFB loop	116	185	1609872, 17296934, 22151997
Invasion & Metastasis	FLT1 mediates survival in post-EMT cancer cells	58	115	14521839
Invasion & Metastasis	IGF1R ->EMT	51	68	19148466, 23994953
Invasion & Metastasis	EDN->EMT	81	143	19880243, 18718806
Invasion & Metastasis	HGF->MET->EMT	63	120	23474222, 23229794
Invasion & Metastasis	PDGF ->EMT	50	66	23261166, 23788982
Invasion & Metastasis	Calveolin -| EMT in lipid rafts	32	43
Invasion & Metastasis	EGF->FOXM1/FOXOA	111	225
Invasion & Metastasis	EGF->EMT	104	230
Invasion & Metastasis	AR->PSA in Prostate Cancer	17	20
Invasion & Metastasis	FoxM1 loop	7	10
Invasion & Metastasis	ECM->EMT	126	256
Invasion & Metastasis	CDH11 adherens junction	16	24	22593800
Invasion & Metastasis	PDGF-D->EMT	85	172	23261166
Invasion & Metastasis	F2 modulation of cytoskeleton	100	172
Invasion & Metastasis	F2 modulation of vascular permeability	62	111
Invasion & Metastasis	Coagulation cascade in cancer	63	73	23691951,11908507,11516455
Invasion & Metastasis	UrokinaseR signaling	45	74
Tumor inflammation	“Find me” signals in apoptotic clearance	90	111	19932201, 23284042, 22871044, 15928001, 22973558
Tumor inflammation	“Eat me” signals in apoptotic clearance	60	113	19932201, 22973558
Tumor inflammation	Transcellular biosynthesis of eicosanoids	28	26	1380800
Tumor inflammation	oxLDL->macrophage activation	58	72
Tumor inflammation	Lymphotoxin B signaling	38	64	20603617
Avoid immune destruction	OSM signaling	168	252
Avoid immune destruction	N1->N2 neutrophil polarization	44	58	21798756
Avoid immune destruction	TANs antitumor activity	13	13	21798756
Avoid immune destruction	TENs kill tumor cells	36	44	21907922
Avoid immune destruction	M1->M2 macrophage polarization	43	48	16269622

EMT: Epithelial-to-Mesenchymal Transition, LDL: Low-Density Lipoprotein, oxLDL: Oxidized LDL, EGFR: Epithelial Growth Factor, ROS: Reactive Oxygen Species, HIF: Hypoxia-Induced Factor, ECM: Extracellular Matrix, F2: Thrombin, TAMs: Tumor Associated Macrophages, TANs: Tumor Associated Neutrophils, TENs: Tumor Entrained Neutrophils