Table
3: Cancer
pathways activated in all three patients. All pathways were enriched with major
expression regulators identified by SNEA with p-value smaller than 0.05
according to Fisher exact test.
|
Pathway |
Cancer hallmark |
|
F2->angiogenesis |
Angiogenesis |
|
VEGFR->endothelial
proliferation |
Angiogenesis |
|
N1->N2
neutrophil polarization |
Avoid
immune destruction |
|
OSM
signaling |
Avoid
immune destruction |
|
ECM->EMT |
Invasion
& Metastasis |
|
Hypoxia->EMT |
Invasion
& Metastasis |
|
TGFB
loop |
Invasion
& Metastasis |
|
PDGF
->EMT |
Invasion
& Metastasis |
|
PDGF-D->EMT |
Invasion
& Metastasis |
|
EGF->EMT |
Invasion
& Metastasis |
|
F2
modulation of vascular permeability |
Invasion
& Metastasis |
|
Coagulation
cascade in cancer |
Invasion
& Metastasis |
|
Calveolin -| EMT in lipid rafts |
Invasion
& Metastasis |
|
IGF1R
->EMT |
Invasion
& Metastasis |
|
Wnt ->EMT |
Invasion
& Metastasis |
|
EGF->FOXM1/FOXOA |
Invasion
& Metastasis |
|
FLT1
mediates survival in post-EMT cancer cells |
Invasion
& Metastasis |
|
F2
modulation of cytoskeleton |
Invasion
& Metastasis |
|
F2
-> STAT1/NF-kB Expression Targets |
Resisting
cell death |
|
F2
-> AP-1/CREB/ELK-SRF/SP1 Expression Targets |
Sustaining
proliferation |
|
EGFR
activation by apoptotic clearance |
Sustaining
proliferation |
|
"Find
me" signals in apoptotic clearance |
Tumor
inflammation |