Table 1: Immunohistochemistry Features of Nipple Epidermal Lesions

 

Paget cells

Toker cells

Melanoma

Cytokeratin 7

positive

positive

negative

Epithelial membrane antigen

positive

negative

negative

Human milk fat globule

positive

negative

negative

GCDFP-15

positive

negative

negative

CEA

positive

negative

negative

HER2/neu

positive

negative

negative

HMB-45

negative

negative

positive

Melan-A

negative

negative

positive

 

GCDFP: gross cystic disease fluid protein; CEA: carcinoembryonic antigen; HMB: human melanoma black