Table 1: Final meta analysis.

 

Identifying data

Population characteristics

MRI

Standard biopsy

Targeted biopsy

Source

Year

Population size

Age

PSA (ng/mL)

Prior biopsy

MRI Series

Field strength (T)

Pelvic array coil/ endorectal coil (y/n)

Grading score

Biopsy type

Cores taken per patient

MRI targeted biopsy

Targeted cores per lesion (avg)

Da Rosa, et al.

2014

72

Mean 64.8

Mean 5.0

100% on active surveillance

T2, DWI, DCE

3

y/n

5-point scale

TRUS

12

MRI computer fusion (Uronav)

2

Fiard, et al.

2013

30

Mean 64

Mean 6.3

Mixed - 43% biopsy na´ve, 57% previous negative

T2, DWI, DCE

3

n/n

PI-RADS

TRUS

12

MRI computer fusion (Urostation)

2

Haffner, et al.

2010

555

Mean 64

Median 6.75

100% biopsy na´ve

T2, DCE

1.5

y/n

5-point scale

TRUS

10-12

MRI cognitive fusion

2

Hu, et al.

2014

90

Median 63

Median 4.2

100% on active surveillance

T2, DWI, DCE

3

y/n

5-point scale

TRUS

12

MRI computer fusion (Artemis)

2

Kasivisvanathan, et al.

2013

182

Mean 63.3

Median 6.7

Mixed - 43% biopsy na´ve, 18% previous negative, 39% on active surveillance

T2, DWI, DCE

1.5 and 3

y/n

5-point scale

Transperineal

20

MRI cognitive fusion

NR

Lawrence, et al.

2014

39

Mean 64

Median 10.0

100% previous negative

T2, DWI

1.5 or 3

y/n

PI-RADS

Transperineal

24-36

MRI computer fusion (Biopsee)

3

Mozer, et al.

2014

152

Mean63

Mean 6.0

100% biopsy na´ve

T2, DWI, DCE

1.5

y/n

5-point scale

TRUS

12

MRI computer fusion (Urostation)

2

*Park, et al.

2011

44

Mean 63

Mean 6.1

100% biopsy na´ve

T2, DWI, DCE

3

NR

Low, moderate, high

TRUS

10-12

MRI cognitive fusion

NR

Pepe et al.

2013

78

Median 63

Median 11.0

100% previous negative

T2, DWI, DCE, MRSI

3

y/n

Low, moderate, high

TRUS

15

MRI cognitive fusion

3.5

Pokorny, et al.

2014

223

Median 63

Median 5.3

100% biopsy na´ve

T2, DWI, DCE, MRSI

3

y/n

PI-RADS

TRUS

NR

MRI In-bore

2.5

Puech, et al.

2013

95

Median 65

Mean 10.05

Mixed - 68% biopsy na´ve, 32% previous negative

T2, DWI, DCE

1.5

y/n

5-point scale

TRUS

12

MRI cognitive fusion and MRI computer fusion (MyLab Navigator)

4

Quentin et al.

2014

128

Mean 66.1

Mean 8.7, Median 6.7

100% biopsy na´ve

T2, DWI, DCE

3

y/n

PI-RADS

TRUS

12

MRI In-bore

2

Radtke et al.

2014

196

Median 64

Mean 7.3

Mixed - 61% biopsy na´ve, 39% previous negative

T2, DWI, DCE

3

y/n

PI-RADS

Transperineal

24

MRI computer fusion (Biopsee)

2

Salami, et al.

2014

140

Median 65

Median 8.0

100% previous negative

T2, DWI, DCE

3

y/y

5-point scale

TRUS

12

MRI computer fusion (Uronav)

2

Shakir, et al.

2014

1,003

Median 62

Median 6.7

Mixed - 20% biopsy na´ve, 80% previous negative

T2, DWI, DCE, MRSI

3

y/y

Low, moderate, high

TRUS

12

MRI computer fusion (Uronav)

2

Somford, et al.

2013

54

Median 65

Mean 6.2

100% on active surveillance

T2, DWI, DCE

3

y/y

Low, moderate, high

TRUS

9-12

MRI In-bore

2

Sonn, et al.

2013

94

Median 65

Median 7.5

100% previous negative

T2, DWI, DCE

3

y/n

5-point scale

TRUS

12 (5 with saturation)

MRI computer fusion (Artemis)

4.2

Wysock, et al.

2014

67

Mean 65

Mean 5.1

100% biopsy na´ve

T2, DWI, DCE

3

y/n

PI-RADS, 5-point scale

TRUS

12

MRI cognitive fusion and MRI computer fusion (Artemis)

4

 

*MRI Group only.