Table 5: Details in patients with brain metastases.
Number of patients (%) | ||
Total | 14 | |
Number of previous regimens for metastatic breast cancer | ||
0 | 0 | |
1 | 4 (29%) | |
2 | 2 (14%) | |
3 | 4 (29%) | |
≥ 4 | 4 (29%) | |
Loco-regional treatment for brain metastases | ||
None | 1 (7%) | |
Surgery | 0 | |
Radiation therapy | 12 (86%) | |
Surgery + radiation therapy | 1 (7%) | |
Response to T-DM1 for brain metastases | ||
Complete response | 0 | |
Partial response | 0 | |
Stable disease | 5 (36%) | |
Progressive disease | 5 (36%) | |
Not evaluable | 4 (29%) | |
Median time to treatment failure, months (range) | 6.0 (0.8-21.0) | |
Adverse events (Grade 3/4) | ||
Thrombocytopenia | 3 (21%) | |
Increased ALT and/or AST | 0 | |
Rash | 0 | |
Neutropenia | 0 |