Table 2: IC50 values for resminostat anti-proliferative activity against NSCLC cells.
Cell | IC50 (μmol/L) | KRAS status | Note |
A437 | 5.3 | wild | |
Calu-3 | 2.0 | wild | |
NCI-H522 | 8.7 | wild | |
NCI-H1975 | 5.0 | wild | EGFR-TKI-resistant |
NCI-H2126 | 3.4 | wild | |
A549 | 3.3 | G12S | |
COR-L23 | 4.2 | G12V | |
MOR/CPR | 0.74 | G12C | CDDP-resistant |
NCI-H23 | 4.4 | G12C | |
NCI-H358 | 0.36 | G12C | |
NCI-H460 | 4.5 | Q61H | CDDP-resistant |