Table 3: Characteristics of angiogenesis inhibitors.

Drug name	Brand name	EGFR ‐ I	TKI	VEGF ‐ I	AI	Mode of administration
Afatinib	Gilotrif	✓	✓		✓	Oral
Axitinib	Inlyta		✓	✓	✓	Oral
Bevacizumab	Avastin			✓	✓	Intravenous, Intravitreal
Bosutinib	Bosulif		✓		✓	Oral
Cabozantinib	Cometriq		✓	✓	✓	Oral
Ceritinib	Zykadia		✓		✓	Oral
Cetuximab	Erbitux	✓			✓	Intravenous
Crizotinib	Xalkori		✓		✓	Oral
Dasatinib	Sprycel		✓		✓	Oral
Erlotinib	Tarceva	✓	✓		✓	Oral
Gefitinib	Iressa	✓	✓		✓	Oral
Ibrutinib	Imbruvica		✓		✓	Oral
Imatinib	Gleevec		✓		✓	Oral
Lapatinib	Tykerb	✓	✓		✓	Oral
Nilotinib	Tasigna		✓		✓	Oral
Panitumumab	Vectibix	✓			✓	Intravenous
Pazopanib	Votrient		✓	✓	✓	Oral
Ponatinib	Iclusig		✓		✓	Oral
Ramucirumab	Cyramza			✓	✓	Intravenous
Regorafenib	Stivarga		✓	✓	✓	Oral
Ruxolitinib	Jakafi		✓		✓	Oral
Sorafenib	Nexavar		✓	✓	✓	Oral
Sunitinib	Sutent		✓	✓	✓	Oral
Vandetanib	Caprelsa	✓	✓	✓	✓	Oral
Ziv‐Aflibercept	Zaltrap			✓	✓	Intravenous

EGFR‐I: Endothelial Growth Factor Receptor Inhibitors; TKI: Tyrosine Kinase Inhibitors; VEGF‐I: Vascular Endothelial Growth Factor Inhibitors; AI: Angiogenesis Inhibitors; ✓: Yes.