Table 5: CTCAE grading of thromboembolic events [41].
| Adverse event | Thromboembolic event | |
|---|---|---|
| Grade 1 | Venous thrombosis (e.g., superficial thrombosis) | |
| Grade 2 | Venous thrombosis (e.g., uncomplicated deep vein thrombosis) | Medical intervention indicated |
| Grade 3 | Thrombosis (e.g., uncomplicated pulmonary embolism [venous], non-embolic cardiac mural [arterial] thrombus) | Medical intervention indicated |
| Grade 4 | Life-threatening (e.g., pulmonary embolism, cerebrovascular event, arterial insufficiency); hemodynamic or neurologic instability |
Urgent intervention indicated |
| Grade 5 | Death |