Table 1: Summarizes all the large trials evaluating the use of exemestane in the adjuvant, metastatic, and preventative settings.

Study Intervention
Adjuvant
Morden JP, et al. [4] Exemestane after 2 to 3 years of tamoxifen
Placido SD, et al. [5] Anastrozole vs. Exemestane vs. Letrozole upfront or after 2 years of tamoxifen
Pagani O, et al. [8] Exemestane plus ovarian suppression vs. Tamoxifen plus ovarian suppression
Goss PE, et al. [13] Exemestane vs. Anastrozole
Derks MG, et al. [7] Tamoxifen and Exemestane switch therapy vs. Exemestane alone
Metastatic
Campos SM, et al. [9] Exemestane vs. Anastrozole
Beresford M, et al. [10] Systematic review
Baselga J, et al. [11] Exemestane and Everolimus vs. Exemestane and Placebo
Prevention
Goss PE, et al. [13] Exemestane vs. Placebo