Covariates

ACT

NACT^*

Adj. β

Adj. HR (95% CI)

Wald statistic

p-value

Adj. β

Adj. HR (95% CI)

Wald statistic

p-value

Age

< 50 years

≥ 50 years

0

2.070

Referent

7.93 (0.91-18.84)

3.52

0.061

0

0.399

Referent

1.49 (0.46-4.85)

0.438

0.508

Ethnic

Malay

Non-Malay

0

0.037

Referent

1.04 (0.35-3.13)

0.04

0.947

0

0.535

Referent

1.70 (0.41-7.25)

0.527

0.468

Stage

Early stage

Advanced stage

0

2.412

Referent

11.16 (2.15-37.90)

8.23

0.004

-

-

-

-

-

-

Molecular subtypes

Luminal A

TNBC

Other

0

1.255

1.170

Referent

1.84 (1.24-2.94)

1.78 (1.14-4.20)

0.08

0.07

0.767

0.790

0

0.511

0.497

Referent

1.60 (0.96-6.52)

1.64 (0.90-6.72)

0.176

0.479

0.675

0.489

Chemotherapy

Anthracycline based

Taxane based

Antharacycline+Taxane

0

2.213

-1.577

Referent

6.15 (1.38-10.54)

0.21 (0.04-1.04)

5.77

3.67

0.022

0.049

0

0.224

1.377

Referent

1.15 (0.82-6.21)

0.96 (0.52-5.34)

0.063

0.097

0.802

0.796

Schedule modification

No Modification

With Modification

0

0.266

Referent

1.31 (0.31-5.52)

0.13

0.718

0

0.214

Referent

1.23 (0.42-3.67)

0.149

0.699