TLR |
Co-Receptors/ other characteristics |
TLR1 |
TLR2 [90] |
TLR2 |
MYD88, TIRAP |
TLR3 |
Cytoplasmic domain dimerization, downstream activation through TICAM-1 [92] |
TLR4 |
Lipoprotein binding protein, CD14, MD2
MyD88, [94] IRAK(IL-1 associated Kinase), TRAF 6, TIRAP , PI (45) p2
|
TLR5 |
MyD88
Flagelin Ipaf/ Naip 5 in macrophages inflammome
|
TLR6 |
MyD88CD14, CD36, TIRAP RP 105, by decreasing the threshold of the concentration needed for recognition and signaling |
TLR7 |
Unc93b1 a 12 pass integral membrane protein on Endoplasmic Reticulum. with TLR9 traffic through the Golgi [98] apparatus to become endosome [10] |
TLR9 |
Unc93b1, MyD88, TLR9 dimer in endosomal compartment that enable signaling [98] |