| TLR | Co-Receptors/ other characteristics |
| TLR1 | TLR2 [90] |
| TLR2 | MYD88, TIRAP |
| TLR3 | Cytoplasmic domain dimerization, downstream activation through TICAM-1 [92] |
| TLR4 | Lipoprotein binding protein, CD14, MD2 MyD88, [94] IRAK(IL-1 associated Kinase), TRAF 6, TIRAP , PI (45) p2 |
| TLR5 | MyD88 Flagelin Ipaf/ Naip 5 in macrophages inflammome |
| TLR6 | MyD88CD14, CD36, TIRAP RP 105, by decreasing the threshold of the concentration needed for recognition and signaling |
| TLR7 | Unc93b1 a 12 pass integral membrane protein on Endoplasmic Reticulum. with TLR9 traffic through the Golgi [98] apparatus to become endosome [10] |
| TLR9 | Unc93b1, MyD88, TLR9 dimer in endosomal compartment that enable signaling [98] |