Table 1: Major islet ECM components and their corresponding receptors.
|ECM protein||Location and Function||Receptors on islet cells|
|Type I collagen||Peri- and intra-islet ECM, provides tensile strength, structural integrity, and survival signalling.||αvβ3, α2β1, DDR2|
|Type IV collagen||Basement membrane, provides microstructural integrity and cell stimulation, attaches to other basement membrane components.||α1β1, DDR1|
|Fibronectin||Basement membrane, arranged in a 3D fibrillar mesh similar to collagen, plays import roles in cell adhesion and development.||αvβ1, αvβ3, α5β1|
|Laminin||Basement membrane, glycoprotein with trimeric structure, important for cell binding, migration, and differentiation.||α1β1, α3β1, α5β1, α6β1|