Table 3: Group comparisons of metabolic parameters at different time points adjusting for covariates.

4000 IU (n = 50) 6000 IU (n = 25)
25(OH)D (ng/ml)
Baseline 22.25 ± 7.19 23.74 ± 5.09
3 months 37.34 ± 12.31* 43.20 ± 15.94*
6 months 37.99 ± 13.22* 40.62 ± 19.39*
P-value groups = 0.232 P-value time = 0.019 P-value interaction = 0.352
Total Cholesterol (mg/dl)
Baseline 213.08 ± 42.30 193.88 ± 41.03
3 months 209.26 ± 43.62 184.68 ± 50.89
6 months 199.84 ± 32.79 180.48 ± 27.53
P-value groups = 0.204 P-value time = 0.954 P-value interaction = 0.605
Triglycerides (mg/dl)
Baseline 182.98 ± 110.11 201.44 ± 91.35
3 months 174.62 ± 109.83 192.20 ± 94.49
6 months 187.08 ± 151.26 172.92 ± 76.87
P-value groups = 0.962 P-value time = 0.250 P-value interaction = 0.167
LDL Cholesterol
Baseline 128.34 ± 40.54 115.56 ± 34.53
3 months 125.88 ± 40.90 120.00 ± 35.37
6 months 120.76 ± 30.35 121.96 ± 40.60
P-value groups = 0.969 P-value time = 0.872 P-value interaction = 0.423
HDL Cholesterol
Baseline 50.64 ± 12.20 42.44 ± 10.40
3 months 48.92 ± 11.12 42.12 ± 12.35
6 months 46.98 ± 10.37 42.12 ± 12.76
P-value groups = 0.088 P-value time = 0.188 P-value interaction = 0.118

Data represented by mean ± standard error. *Represents significant differences from baseline. Level of significance is at P < 0.05.

25(OH)D: serum vitamin D; LDL: low density lipoprotein; HDL: high density lipoprotein; Analysis was adjusted for age, gender,

years with diabetes, smoking, BMI, vitamin D intake, sun exposure score, fasting plasma glucose, upper arm skin color, forearm skin color, and lipid lowering medication use.