Table 1: Effect of IRC on Fasting Blood Glucose Level in Diabetic Rats after Single Oral Dose Administration.
Group | Dose Mg/kg | Before Alloxan | After Alloxan (0 hr) | Blood glucose (mg/dl) at different time intervals (hrs) | |||||
2 hrs | 4 hrs | 6 hrs | 8 hrs | 24 hrs | ANOVA | ||||
I-Diabetic Control | - | 96.67 ± 2.61 | 394.0 ± 25.5 | 426.7 ± 25.5 | 422.3 ± 26.7 | 396.5 ± 16.4 | 372.2 ± 7.3 | 370.2 ± 7.3 | 0.1342 |
II-Diabetic + IRC | 50 | 96.83 ± 2.51 | 338.8 ± 2.97 | 379.2 ± 54.04 | 378.8 ± 3.49 | 363.7 ± 4.7 | 341.0 ± 8.8 | 358.5 ± 8.0 | 0.3799 |
III-Diabetic + IRC | 500 | 93.00 ± 2.05 | 322.2 ± 2.27 | 375.5 ± 4.80 | 367.0 ± 7.26 | 347.2 ± 12.3 | 335.2 ± 11.43 | 350.5 ± 5.9 | 0.0003 |
IV-Diabetic + IRC | 1000 | 92.33 ± 1.87 | 349.0 ± 9.94 | 365.5 ± 11.2 | 361.5 ± 7.94 | 339.0 ± 12.2 | 338.0 ± 12.2 | 328.3 ± 12.2 | 0.0401 |
V-Diabetic + IRC | 2000 | 86.67 ± 1.17 | 331.70 ± 7.36 | 345.50 ± 5.34 | 348.30 ± 7.94 | 331.00 ± 7.94 | 323.70 ± 7.68 | 320.20 ± 6.09 | 0.0248 |
Dose Depend Effect | 0.0032 | 0.0077 | 0.0044 | 0.0214 | 0.0018 | ||||
VI-Diabetic + glibencla | 5 | 92.83 ± 5.64 | 283.5 ± 12.78 | 234.7 ± 10.82 | 196.8 ± 7.60 | 188.5 ± 9.24 | 186.8 ± 6.61 | 188.5 ± 29.72 | < 0.0001 |
Each value represent mean ± SEM (n = 6 rats per group).
0 hr = 48 hours after alloxan.