Table 1: Metabolic and hemodynamic responses at rest, during and after exercise in T2D patients and control subjects.
|
|
T2D (n = 8) |
Control (n = 7) |
P |
|
Resting |
|
|
|
|
PCr (mM) |
37.87 ± 3.24 |
41.09 ± 2.14 |
0.04 |
|
Pi (mM) |
5.97 ± 0.99 |
4.78 ± 1.06 |
0.04 |
|
PCr/Pi |
6.52 ± 1.30 |
8.93 ± 1.81 |
0.01 |
|
Cr (mM) |
5.68 ± 0.49 |
6.16 ± 0.32 |
0.04 |
|
ADP (uM) |
7.78 ± 0.29 |
7.67 ± 0.72 |
0.678 |
|
pH |
7.02 ± 0.02 |
7.02 ± 0.05 |
0.880 |
|
Exercise & Recovery |
|
|
|
|
SSI Ex. Duration (s) |
321.00 ± 116.77 |
420.00 ± 105.48 |
0.03 |
|
NIRS |
|
|
|
|
End Hb/Mb-oxy (%) |
24.88 ± 6.91 |
30.39 ± 13.82 |
0.547 |
|
T50 (s) |
77.35 ± 55.21 |
30.80 ± 8.60 |
0.05 |
|
Recovery Delay (s) |
32.41 ± 16.53 |
14.18 ± 7.02 |
0.02 |
|
DBV (%) |
-5.12 ± 55.87 |
65.90 ± 22.73 |
0.008 |
|
BFindex (%/s) |
4.98 ± 2.17 |
10.11 ± 3.90 |
0.01 |
|
MRS |
|
|
|
|
End PCr (%) |
46.31 ± 16.81 |
49.40 ± 17.60 |
0.745 |
|
dPCr/dt (%/s) |
-4.00 ± 1.80 |
-3.73 ± 1.79 |
0.786 |
|
PCrre (mM/kg/min) |
22.31 ± 13.35 |
49.37 ± 36.62 |
0.015 |
|
Tc (s) |
67.21 ± 69.51 |
35.59 ± 23.65 |
0.119 |
|
pH End ex. (12-s) |
6.979 ± 0.047 |
7.006 ± 0.034 |
0.634 |
|
pH End ex. (SS) |
6.893 ± 0.084 |
6.954 ± 0.083 |
0.165 |
|
pH 1 min post (12-s) |
6.910 ± 0.043 |
7.007 ± 0.057 |
0.002 |
|
pH 1 min post (ss) |
6.851 ± 0.086 |
6.955 ± 0.076 |
0.028 |
Note: PCr: Phosphocreatine; Pi: Inorganic phosphate; PCr/Pi: Ratio of PCr to Pi concentration; ipH: intracellular pH; T50NIR: Time to 50% of Hemoglobin/Myoglobin-reoxygenation from cessation of exercise; DBV: Blood volume change, BFindex: Blood flow index; End PCr: End exercise PCr; dPCr/dt: Change in PCr over change in time; PCrre: Phosphocreatine resynthesis rate; Tc: Time constant; 12-s: 12-s all out exercise; ss: steady state incremental exercise. Data are expressed in mean ± SD.